| Gene Symbol |
Mapk14
|
| Entrez Gene |
26416
|
| Alt Symbol |
CSBP2, Crk1, Csbp1, Mxi2, PRKM14, PRKM15, p38, p38-alpha, p38MAPK, p38a, p38alpha
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase 14
|
| Other Description |
MAP kinase 14|MAP kinase p38 alpha|MAPK 14|cytokine suppressive anti-inflammatory drug binding protein 1|mitogen activated protein kinase 14|mitogen-activated protein kinase p38 alpha|p38 MAP kinase alpha|p38 MAPK|p38 alpha|tRNA synthetase cofactor p38
|
| Swissprots |
Q9QZ80 Q9JLV8 Q3UZS3 P47811 Q8C289 B2KF38 B2KF37 O08666 Q3U6R5
|
| Accessions |
EDL22584 EDL22585 EDL22586 EDL22587 P47811 AF128892 AAF34818 AF195850 AAF06348 AI132714 AK089059 BAC40726 AK133684 BAE21782 AK151348 BAE30324 AK153025 BAE31659 AK177608 AK178357 AK185139 AK191704 AK192555 AK195023 AK199780 AK201673 AK205426 AK210155 AK210810 AK216421 AK218544 AK219197 BC012235 AAH12235 BC018227 BC085303 AAH85303 CX568915 D83073 BAA19741 U10871 AAA20888 X65067 CAA46200 NM_001168508 NP_001161980 NM_001168513 NP_001161985 NM_001168514 NP_001161986 NM_011951 NP_036081
|
| Function |
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mito
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:10601328}. Nucleus {ECO:0000269|PubMed:10601328}.
|
| Tissue Specificity |
Macrophages, monocytes, T- and B-lymphocytes. Isoform 2 is specifically expressed in kidney and liver.
|
| Top Pathways |
Adrenergic signaling in cardiomyocytes, Proteoglycans in cancer, Sphingolipid signaling pathway, Prolactin signaling pathway, Rap1 signaling pathway
|
