Mapk14

Gene Symbol	Mapk14
Entrez Gene	26416
Alt Symbol	CSBP2, Crk1, Csbp1, Mxi2, PRKM14, PRKM15, p38, p38-alpha, p38MAPK, p38a, p38alpha
Species	Mouse
Gene Type	protein-coding
Description	mitogen-activated protein kinase 14
Other Description	MAP kinase 14|MAP kinase p38 alpha|MAPK 14|cytokine suppressive anti-inflammatory drug binding protein 1|mitogen activated protein kinase 14|mitogen-activated protein kinase p38 alpha|p38 MAP kinase alpha|p38 MAPK|p38 alpha|tRNA synthetase cofactor p38
Swissprots	Q9QZ80 Q9JLV8 Q3UZS3 P47811 Q8C289 B2KF38 B2KF37 O08666 Q3U6R5
Accessions	EDL22584 EDL22585 EDL22586 EDL22587 P47811 AF128892 AAF34818 AF195850 AAF06348 AI132714 AK089059 BAC40726 AK133684 BAE21782 AK151348 BAE30324 AK153025 BAE31659 AK177608 AK178357 AK185139 AK191704 AK192555 AK195023 AK199780 AK201673 AK205426 AK210155 AK210810 AK216421 AK218544 AK219197 BC012235 AAH12235 BC018227 BC085303 AAH85303 CX568915 D83073 BAA19741 U10871 AAA20888 X65067 CAA46200 NM_001168508 NP_001161980 NM_001168513 NP_001161985 NM_001168514 NP_001161986 NM_011951 NP_036081
Function	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mito
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10601328}. Nucleus {ECO:0000269|PubMed:10601328}.
Tissue Specificity	Macrophages, monocytes, T- and B-lymphocytes. Isoform 2 is specifically expressed in kidney and liver.
Top Pathways	Adrenergic signaling in cardiomyocytes, Proteoglycans in cancer, Sphingolipid signaling pathway, Prolactin signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® p38α MAPK siRNA II (Mouse Specific) - 6418 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® p38α MAPK siRNA I (Mouse Specific) - 6417 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Mouse

p38α CRISPR/Cas9 KO Plasmid (m) - sc-424051 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

p38α HDR Plasmid (m) - sc-424051-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

p38α Double Nickase Plasmid (m) - sc-424051-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

p38α Double Nickase Plasmid (m2) - sc-424051-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

p38α CRISPR Activation Plasmid (m) - sc-424051-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

p38α CRISPR Activation Plasmid (m2) - sc-424051-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

p38α Lentiviral Activation Particles (m) - sc-424051-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

p38α Lentiviral Activation Particles (m2) - sc-424051-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

p38α siRNA (m) - sc-29434 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

p38α shRNA Plasmid (m) - sc-29434-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

p38α shRNA (m) Lentiviral Particles - sc-29434-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

p38α siRNA (m2) - sc-44217 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

p38α shRNA Plasmid (m2) - sc-44217-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

p38α shRNA (m2) Lentiviral Particles - sc-44217-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

MISSION® esiRNA - EMU021961 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN35257 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND35257 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MAPK14 siRNA (Mouse) - CRM4730 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

shRNA set against Mouse MAPK14 (NM_011951.3) - SHH337983 from Creative biogene Category siRNA Species Reactivities Mouse

Mouse MAPK14 siRNA - orb284206 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

MAPK14 shRNA Plasmid (Mouse) - CHM4730 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Mouse

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