FMR1

Gene Symbol	FMR1
Entrez Gene	2332
Alt Symbol	FMRP, FRAXA, POF, POF1
Species	Human
Gene Type	protein-coding
Description	fragile X mental retardation 1
Other Description	fragile X mental retardation protein 1
Swissprots	G8JL90 D3DWT0 D3DWT2 Q5PQZ6 A6NNH4 Q16578 Q99054 Q06787 D3DWT1
Accessions	AAA62452 AAA62453 AAA62454 AAA62455 AAA62456 AAA62457 AAA62458 AAA62459 AAA62460 AAA62461 AAA62462 AAA62463 AAA62464 AAA62465 AAA62466 AAA62467 AAA62468 AAA62469 AAB18828 AAB18829 AAB18830 AAB18831 AAB18832 AAB18833 AAD14228 EAW61293 EAW61294 EAW61295 EAW61296 EAW61297 EAW61298 EAW61299 EAW61300 EAW61301 EAW61302 EAW61303 Q06787 AB209188 BAD92425 AK294104 BAG57439 AK302707 BAG63929 BC038998 AAH38998 BC086957 AAH86957 BQ213316 BQ287827 BQ417290 BX498094 CK825936 CN315330 CX871385 KC774027 AGO02164 KC774028 AGO02165 KC774029 AGO02166 KF856234 AHI43787 KJ534836 AHW56476 KJ534837 AHW56477 KJ534838 AHW56478 M67468 AAA52458 S65791 AAB28395 X69962 CAA49586 NM_001185075 NP_001172004 NM_001185076 NP_001172005 NM_001185081 NP_001172010 NM_001185082 NP_001172011 NM_002024 NP_002015 NR_033699 NR_033700
Function	Translation repressor. Component of the CYFIP1-EIF4E- FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA- binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C). {ECO:0000250}.
Subcellular Location	Cytoplasm. Nucleus, nucleolus.
Tissue Specificity	Highest levels found in neurons, brain, testis, placenta and lymphocytes. Also expressed in epithelial tissues and at very low levels in glial cells. {ECO:0000269|PubMed:8401578, ECO:0000269|PubMed:8504300}.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FMRP (phospho S499) peptide - ab48658 from Abcam Category Peptide

Human FMRP full length protein - ab132093 from Abcam Category Protein Source Wheat germ Species Human

Human FMRP peptide - ab19074 from Abcam Category Peptide

Human FMRP peptide - ab19073 from Abcam Category Peptide

Human FMRP peptide - ab48659 from Abcam Category Peptide

Human FMRP protein fragment - ab114231 from Abcam Category Protein Source Wheat germ Species Human

FMR1 / FMRP Antibody Blocking Peptide - LS-E14717 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FMR1 / FMRP Antibody Blocking Peptide - LS-E8521 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FMR1 / FMRP Antibody Blocking Peptide - LS-E26378 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FMR1 / FMRP Antibody Blocking Peptide - LS-E27066 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human FMRP Protein - H00002332-P01 from Novus Biologicals Category Protein Prices $319.00, $369.00, $529.00 Sizes 2 µg, 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human FMRP Protein - H00002332-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FMR1-Antibody-N-term-Blocking-Peptide - BP6879a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FMRP (aa116-130) blocking peptide - GTX88417-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Rat

FMRP blocking peptide - GTX88748-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

FMR1 Immunizing peptide - orb59570 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

FMRP (OVA) peptide - orb197997 from Biorbyt Category Peptide Prices $434.00 Sizes 100 μg Species Human, Mouse, Rat, Rabbit, Guinea Pig, Monkey, Dog, Horse, Pig, Sheep, Hamster

Fmr1 Blocking Peptide - 33R-7588 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FMRP Peptide - AC21-1213-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

FMRP Peptide - AC21-1888-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

FMR1 / FMRP - H00002332-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

FMR1 / FMRP - H00002332-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

FMR1 / FMRP - H00002332-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

FMR1 / FMRP - H00002332-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

FMR1 Peptide - 42-001P from ProSci Category Peptide Species Human

Search more