FMR1

Gene Symbol	FMR1
Entrez Gene	2332
Alt Symbol	FMRP, FRAXA, POF, POF1
Species	Human
Gene Type	protein-coding
Description	fragile X mental retardation 1
Other Description	fragile X mental retardation protein 1
Swissprots	G8JL90 D3DWT0 D3DWT2 Q5PQZ6 A6NNH4 Q16578 Q99054 Q06787 D3DWT1
Accessions	AAA62452 AAA62453 AAA62454 AAA62455 AAA62456 AAA62457 AAA62458 AAA62459 AAA62460 AAA62461 AAA62462 AAA62463 AAA62464 AAA62465 AAA62466 AAA62467 AAA62468 AAA62469 AAB18828 AAB18829 AAB18830 AAB18831 AAB18832 AAB18833 AAD14228 EAW61293 EAW61294 EAW61295 EAW61296 EAW61297 EAW61298 EAW61299 EAW61300 EAW61301 EAW61302 EAW61303 Q06787 AB209188 BAD92425 AK294104 BAG57439 AK302707 BAG63929 BC038998 AAH38998 BC086957 AAH86957 BQ213316 BQ287827 BQ417290 BX498094 CK825936 CN315330 CX871385 KC774027 AGO02164 KC774028 AGO02165 KC774029 AGO02166 KF856234 AHI43787 KJ534836 AHW56476 KJ534837 AHW56477 KJ534838 AHW56478 M67468 AAA52458 S65791 AAB28395 X69962 CAA49586 NM_001185075 NP_001172004 NM_001185076 NP_001172005 NM_001185081 NP_001172010 NM_001185082 NP_001172011 NM_002024 NP_002015 NR_033699 NR_033700
Function	Translation repressor. Component of the CYFIP1-EIF4E- FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA- binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C). {ECO:0000250}.
Subcellular Location	Cytoplasm. Nucleus, nucleolus.
Tissue Specificity	Highest levels found in neurons, brain, testis, placenta and lymphocytes. Also expressed in epithelial tissues and at very low levels in glial cells. {ECO:0000269|PubMed:8401578, ECO:0000269|PubMed:8504300}.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

FMR1 CRISPR/Cas9 KO Plasmid (h) - sc-401919 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FMR1 HDR Plasmid (h) - sc-401919-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FMR1 Double Nickase Plasmid (h) - sc-401919-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FMR1 Double Nickase Plasmid (h2) - sc-401919-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FMR1 CRISPR Activation Plasmid (h) - sc-401919-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FMR1 CRISPR Activation Plasmid (h2) - sc-401919-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FMR1 Lentiviral Activation Particles (h) - sc-401919-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FMR1 Lentiviral Activation Particles (h2) - sc-401919-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FMR1 siRNA (h) - sc-36870 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

FMR1 shRNA Plasmid (h) - sc-36870-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

FMR1 shRNA (h) Lentiviral Particles - sc-36870-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

FMRP RNAi - H00002332-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

FMRP RNAi - H00002332-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU082131 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8847 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8847 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

FMR1 siRNA (Human) - CRH1635 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

FMR1 - MBS8204677 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human FMR1 (NM_002024.5) - SHH296001 from Creative biogene Category siRNA Species Reactivities Human

Human FMR1 siRNA - orb262137 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

FMR1 shRNA Plasmid (Human) - CHH1635 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

FMR1 miRNA 3'UTR clone - MiUTR4H-TG03582 from Creative biogene Species Reactivities Human

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