Gene Symbol | ANXA2 |
---|---|
Entrez Gene | 302 |
Alt Symbol | ANX2, ANX2L4, CAL1H, HEL-S-270, LIP2, LPC2, LPC2D, P36, PAP-IV |
Species | Human |
Gene Type | protein-coding |
Description | annexin A2 |
Other Description | annexin II|annexin-2|calpactin I heavy chain|calpactin I heavy polypeptide|calpactin-1 heavy chain|chromobindin 8|chromobindin-8|epididymis secretory protein Li 270|lipocortin II|placental anticoagulant protein IV|protein I |
Swissprots | Q8TBV2 Q6N0B3 Q567R4 Q9UDH8 Q96DD5 P07355 |
Accessions | CAH59520 EAW77582 EAW77583 EAW77584 EAW77585 EAW77586 EAW77587 P07355 AA661718 AK092006 BAG52463 AK124427 AK222542 AK297923 BAG60240 AK309356 AW087150 BC001388 AAH01388 BC001748 BC009564 AAH09564 BC013843 BC015834 AAH15834 BC016774 AAH16774 BC021114 AAH21114 BC023990 AAH23990 BC052558 AAH52558 BC052567 AAH52567 BC066955 AAH66955 BC068065 AAH68065 BC093056 AAH93056 BT007432 AAP36100 BX640598 CAE45704 D00017 BAA00013 D28364 BAA05730 DQ891008 ABM81934 DQ894187 ABM85113 FJ224302 ACI45994 XM_011521475 XP_011519777 XM_011521476 XP_011519778 XM_011521477 XP_011519779 NM_001002857 NP_001002857 NM_001002858 NP_001002858 NM_001136015 NP_001129487 NM_004039 NP_004030 |
Function | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. |
Subcellular Location | Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism. |