| Gene Symbol |
Gnas
|
| Entrez Gene |
24896
|
| Alt Symbol |
Gnas1, Gnpas, Nesp55
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
GNAS complex locus
|
| Other Description |
G-alpha-8|GNAS|GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus|adenylate cyclase-stimulating G alpha protein|gnas {ECO:0000312|RGD:2716}|guanine nucleotide binding protein alpha s|guanine nucleotide-binding protein G-s, alpha subunit
|
| Swissprots |
Q792G6 P04894 Q05087 P08755 Q9Z1R8 Q45QM7 P63095
|
| Accessions |
AAD03032 AAD03033 EDL85091 P63095 Q63803 Q792G6 Q9Z213 AF105254 AAF63227 AF107844 AAD11801 AF107845 AAD11803 AF184151 AAF37806 BC061967 AAH61967 BC158589 AAI58590 BC168156 AAI68156 BF394587 CB770483 DQ120475 AAZ23814 DQ120476 AAZ23815 FQ212511 FQ214546 FQ219804 FQ226208 L10326 AAA41664 M12673 AAA41261 M17525 AAA40827 X84047 CAC39211 NM_019132 NP_062005 NM_001024823 NP_001019994 NM_001159653 NP_001153125 NM_001159656 NP_001153128 NM_021845 NP_068617
|
| Function |
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Stimulates the Ras signaling pathway via RAPGEF2 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}. Secreted {ECO:0000250}. Note=Neuroendocrine secretory granules. {ECO:0000250}.
|
| Tissue Specificity |
Isoform Gnas-3 is abundant in brain with intermediate levels in skeletal muscle and very low levels in other tissues. {ECO:0000269|PubMed:8486667}.
|
| Top Pathways |
Oxytocin signaling pathway, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Inflammatory mediator regulation of TRP channels, Long-term depression
|