| Gene Symbol |
SLC26A6
|
| Entrez Gene |
65010
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 26 (anion exchanger), member 6
|
| Other Description |
anion exchange transporter|anion transporter 1|pendrin L1|solute carrier family 26 member 6|solute carrier family 26, member 6|sulfate anion transporter
|
| Swissprots |
Q9NQU1 Q548A7 B4DMZ1 Q96Q90 Q9BXS9
|
| Accessions |
AAF20748 EAW64900 EAW64901 EAW64902 EAW64903 EAW64904 EAW64905 EAW64906 EAW64907 EAW64908 EAW64909 EAW64910 EAW64911 EAW64912 EAW64913 Q9BXS9 AB033288 BAB69041 AB102713 BAC56861 AB208936 BAD92173 AF161369 AAF28929 AF279265 AAF81911 AF288410 AAK19153 AF416721 AAN07094 AK056237 BAB71126 AK297695 BAG60053 AL050170 CAB43306 BC017697 AAH17697 DA702248 DQ891721 ABM82647 EU176609 ABW03410 EU832127 ACE87477 NM_001040454 NP_001035544 NM_001281732 NP_001268661 NM_001281733 NP_001268662 NM_022911 NP_075062 NM_134263 NP_599025 NM_134426 NP_602298
|
| Function |
Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride- formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventi
|
| Subcellular Location |
Isoform 5: Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Ubiquitous. Highest levels in kidney and pancreas. Lower expression in heart, skeletal muscle, liver and placenta. Also found in lung and brain. Isoform 4 is ubiquitously expressed. Isoform 6 is expressed in heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis and ovary. Isoform 5 is expressed weakly in placenta, lung, liver and pancreas. {ECO:0000269|PubMed:11087667, ECO:0000269|PubMed:11247665}.
|
| Top Pathways |
Mineral absorption
|
