SLC26A6

Gene Symbol SLC26A6
Entrez Gene 65010
Alt Symbol -
Species Human
Gene Type protein-coding
Description solute carrier family 26 (anion exchanger), member 6
Other Description anion exchange transporter|anion transporter 1|pendrin L1|solute carrier family 26 member 6|solute carrier family 26, member 6|sulfate anion transporter
Swissprots Q9NQU1 Q548A7 B4DMZ1 Q96Q90 Q9BXS9
Accessions AAF20748 EAW64900 EAW64901 EAW64902 EAW64903 EAW64904 EAW64905 EAW64906 EAW64907 EAW64908 EAW64909 EAW64910 EAW64911 EAW64912 EAW64913 Q9BXS9 AB033288 BAB69041 AB102713 BAC56861 AB208936 BAD92173 AF161369 AAF28929 AF279265 AAF81911 AF288410 AAK19153 AF416721 AAN07094 AK056237 BAB71126 AK297695 BAG60053 AL050170 CAB43306 BC017697 AAH17697 DA702248 DQ891721 ABM82647 EU176609 ABW03410 EU832127 ACE87477 NM_001040454 NP_001035544 NM_001281732 NP_001268661 NM_001281733 NP_001268662 NM_022911 NP_075062 NM_134263 NP_599025 NM_134426 NP_602298
Function Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride- formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventi
Subcellular Location Isoform 5: Cell membrane; Multi-pass membrane protein.
Tissue Specificity Ubiquitous. Highest levels in kidney and pancreas. Lower expression in heart, skeletal muscle, liver and placenta. Also found in lung and brain. Isoform 4 is ubiquitously expressed. Isoform 6 is expressed in heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis and ovary. Isoform 5 is expressed weakly in placenta, lung, liver and pancreas. {ECO:0000269|PubMed:11087667, ECO:0000269|PubMed:11247665}.
Top Pathways Mineral absorption

SLC26A6 (C-17) - sc-26728 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SLC26A6 (C-17): sc-26728. Western blot analysis of SLC26A6 expression in 293T whole cell lysate.

SLC26A6 (H-125) - sc-367839 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-SLC26A6 antibody - ab156935 from Abcam

Host Goat
Clonality Polyclonal
Anti-SLC26A6 antibody (ab156935) at 0.1 µg/ml + Human pancreas lysate at 35 µgdeveloped using the ECL technique

Anti-SLC26A6 antibody - ab99559 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human kidney tissue, staining SLC26A6 with ab99559 at 0.1 &microg/ml. Antigen retrieval was performed by microwaving in a citrate buffer (pH 6). The image on the right was treated with the immunizing peptide.

Anti-SLC26A6 antibody - ab67959 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-SLC26A6 antibody (ab67959) at 1/500 dilutionLane 1 : SLC26A6 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-SLC26A6 antibody - ab123001 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SLC26A6 antibody (ab123001) at 1 µg/ml + PANC1 cell lysate at 10 µg

Anti-SLC26A6 antibody - ab172684 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SLC26A6 antibody (ab172684) at 1 µg/mlLane 1 : SLC26A6 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-SLC26A6 / PAT1 Antibody - LS-C126309 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-SLC26A6 / PAT1 Antibody (aa469-693) - LS-C311878 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC26A6 / PAT1 Antibody (aa613-662) - LS-C146115 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SLC26A6 antibody LS-C146115 Western blot of PANC1 Cell lysate. Antibody concentration 1 ug/ml.

Anti-SLC26A6 / PAT1 Antibody - LS-C179272 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SLC26A6 Antibody - H00065010-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: SLC26A6 Antibody [H00065010-B01P] - Analysis of SLC26A6 expression in transfected 293T cell line by SLC26A6 polyclonal antibody. Lane 1: SLC26A6 transfected lysate(83.38 KDa). Lane 2: Non-transfected lysate.

SLC26A6 Antibody - H00065010-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: SLC26A6 Antibody [H00065010-A01] - SLC26A6 polyclonal antibody (A01), Lot # 070510JCS1 Western Blot analysis of SLC26A6 expression in HeLa ( Cat # L013V1 ).

SLC26A6 Antibody - H00065010-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: SLC26A6 Antibody [H00065010-D01P] - Analysis of SLC26A6 expression in transfected 293T cell line by SLC26A6 polyclonal antibody.Lane 1: SLC26A6 transfected lysate(82.80 KDa).Lane 2: Non-transfected lysate.

SLC26A6 Antibody - H00065010-D01 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC26A6 antibody produced in mouse - SAB1407913 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SLC26A6: <B>Cat. No. SAB1407913</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~83.4 kDa using SLC26A6 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-SLC26A6 (26-40) antibody produced in rabbit - SAB1102582 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human SLC26A6 was separated on SDS-PAGE, blotted with Anti-SLC26A6 (26-40) (<B>Cat. No. SAB1102582</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:500 <BR/>2. Antibody dilution 1:500 + SLC26A6 immunizing peptide (human, 26-40)

Anti-SLC26A6 antibody produced in rabbit - HPA048363 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SLC26A6: <B>Cat. No. HPA048363</B>: Immunohistochemical staining of human kidney shows strong cytoplasmic, membranous and nuclear positivity in tubular cells.

Anti-SLC26A6 antibody produced in goat - SAB2501959 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SLC26A6<B>Cat. No. SAB2501959</B>: Immunohistochemistry (0.1 mg/mL) overnight staining of paraffin embedded Human Kidney. Microwaved antigen retrieval with citrate buffer pH 6, CY3-staining. Data provided by Dean Karaica, B. Sc., and Ivan Sabolic, M.D., Ph.D., Institute for Medical Research and Occupational Health.

Anti-SLC26A6 antibody produced in goat - SAB2501960 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SLC26A6<B>Cat. No. SAB2501960</B>: Immunoblotting (0.1 μg/mL) staining of Human Pancreas lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

SLC26A6 antibody - C-terminal region (ARP61481_P050) - ARP61481_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SLC26A6-Antibody-internal-region - AF3161a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF3161a (0.1 µg/ml) staining of Human Pancreas lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

SLC26A6-Antibody-internal-region - AF3160a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF3160a (10 µg/ml) staining of Human renal cortical brush-border membrane lysate (90 µg protein denatured at 37C for 30min) with (B) and without (A) blocking with the immunizing peptide. Primary incubation was overnight at 4C. Detected by NBT/BCIP. Data kindly provided by Dean Karaica, B. Sc., and Ivan Sabolic, M.D., Ph.D., Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Goat anti-SLC26A6 middle region Antibody (OAEB02668) - OAEB02668 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Goat anti-SLC26A6 middle region Antibody (OAEB02669) - OAEB02669 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
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