| Gene Symbol | CD209 |
|---|---|
| Entrez Gene | 30835 |
| Alt Symbol | CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD209 molecule |
| Other Description | C-type lectin domain family 4 member L|C-type lectin domain family 4, member L|CD209 antigen|HIV gpl20-binding protein|dendritic cell-specific ICAM-3-grabbing non-integrin 1|dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin |
| Swissprots | Q96QQ6 Q96QQ4 Q96QQ5 A8MVQ9 Q96QQ2 G5E9C4 Q96QP8 Q96QP7 Q96QQ7 A8KAM4 Q96QP9 Q96QQ1 Q96QQ0 Q9NNX6 Q96QQ8 Q2TB19 Q96QQ3 |
| Accessions | AAG13814 CAG26528 CAJ18838 EAW68991 EAW68992 EAW68993 EAW68994 EAW68995 EAW68996 EAW68997 EAW68998 EAW68999 EAW69000 EAW69001 Q9NNX6 AF290886 AAK20997 AK057212 AK293089 BAF85778 AK304190 BAG65070 AK308595 AK313585 BAG36354 AY042221 AAK91846 AY042222 AAK91847 AY042223 AAK91848 AY042224 AAK91849 AY042225 AAK91850 AY042226 AAK91851 AY042227 AAK91852 AY042228 AAK91853 AY042229 AAK91854 AY042230 AAK91855 AY042231 AAK91856 AY042232 AAK91857 AY042233 AAK91858 BC110615 AAI10616 M98457 AAF77072 XM_005272472 XP_005272529 NM_001144893 NP_001138365 NM_001144894 NP_001138366 NM_001144895 NP_001138367 NM_001144896 NP_001138368 NM_001144897 NP_001138369 NM_001144899 NP_001138371 NM_021155 NP_066978 NR_026692 |
| Function | Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri- mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA. |
| Subcellular Location | Isoform 11: Secreted {ECO:0000305}. |
| Tissue Specificity | Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes. {ECO:0000269|PubMed:11257134, ECO:0000269|PubMed:11337487}. |
| Top Pathways | Phagosome, Measles, Tuberculosis |
CD209 antigen (CD209), Human, ELISA Kit - CSB-EL004899HU from ARP American Research Products
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CD209 antigen (CD209), Human, ELISA Kit - E01C1470 from ARP American Research Products
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CD209 antigen, CD209, Human, ELISA Kit - E1846h from ARP American Research Products
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DC Specific Intercellular Adhesion Molecule 3-Grabbing Nonintegrin, DC-SIGN/CD209, Rat, ELISA Kit - E-EL-R0318 from ARP American Research Products
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CD209 (Human) IP-WB Antibody Pair - H00030835-PW1 from Acris Antibodies
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CD209 (Human) IP-WB Antibody Pair - H00030835-PW2 from Acris Antibodies
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CD209 (Human) Matched Antibody Pair - H00030835-AP11 from Acris Antibodies
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CD209 (Human) Matched Antibody Pair - H00030835-AP21 from Acris Antibodies
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Human DC-SIGN/CD209 ELISA Kit - HD0238 from NeoScientific
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Guinea Pig DC-SIGN/CD209 ELISA Kit - GD0238 from NeoScientific
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Goat DC-SIGN/CD209 ELISA Kit - GTD0238 from NeoScientific
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Rabbit DC-SIGN/CD209 ELISA Kit - RTD0238 from NeoScientific
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Anserine DC-SIGN/CD209 ELISA Kit - AD0238 from NeoScientific
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CD209 antigen (CD209), ELISA Kit - MBS7229462 from MyBioSource
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CD209 antigen (CD209), ELISA Kit - MBS7243799 from MyBioSource
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CD209 antigen (CD209), ELISA Kit - MBS7244341 from MyBioSource
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CD209 antigen (CD209), ELISA Kit - MBS7215714 from MyBioSource
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CD209 antigen (CD209), ELISA Kit - MBS7209339 from MyBioSource
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CD209 antigen (CD209), ELISA Kit - MBS7212702 from MyBioSource
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CD209 antigen (CD209), ELISA Kit - MBS7217065 from MyBioSource
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CD209 antigen (CD209), ELISA Kit - MBS7221705 from MyBioSource
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CD209 antigen (CD209), ELISA Kit - MBS7222985 from MyBioSource
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CD209 antigen (CD209), ELISA Kit - MBS7206875 from MyBioSource
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CD209 antigen (CD209), ELISA Kit - MBS7251946 from MyBioSource
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CD209 antigen (CD209), ELISA Kit - MBS7238651 from MyBioSource
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