CD209

Gene Symbol	CD209
Entrez Gene	30835
Alt Symbol	CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1
Species	Human
Gene Type	protein-coding
Description	CD209 molecule
Other Description	C-type lectin domain family 4 member L|C-type lectin domain family 4, member L|CD209 antigen|HIV gpl20-binding protein|dendritic cell-specific ICAM-3-grabbing non-integrin 1|dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin
Swissprots	Q96QQ6 Q96QQ4 Q96QQ5 A8MVQ9 Q96QQ2 G5E9C4 Q96QP8 Q96QP7 Q96QQ7 A8KAM4 Q96QP9 Q96QQ1 Q96QQ0 Q9NNX6 Q96QQ8 Q2TB19 Q96QQ3
Accessions	AAG13814 CAG26528 CAJ18838 EAW68991 EAW68992 EAW68993 EAW68994 EAW68995 EAW68996 EAW68997 EAW68998 EAW68999 EAW69000 EAW69001 Q9NNX6 AF290886 AAK20997 AK057212 AK293089 BAF85778 AK304190 BAG65070 AK308595 AK313585 BAG36354 AY042221 AAK91846 AY042222 AAK91847 AY042223 AAK91848 AY042224 AAK91849 AY042225 AAK91850 AY042226 AAK91851 AY042227 AAK91852 AY042228 AAK91853 AY042229 AAK91854 AY042230 AAK91855 AY042231 AAK91856 AY042232 AAK91857 AY042233 AAK91858 BC110615 AAI10616 M98457 AAF77072 XM_005272472 XP_005272529 NM_001144893 NP_001138365 NM_001144894 NP_001138366 NM_001144895 NP_001138367 NM_001144896 NP_001138368 NM_001144897 NP_001138369 NM_001144899 NP_001138371 NM_021155 NP_066978 NR_026692
Function	Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri- mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA.
Subcellular Location	Isoform 11: Secreted {ECO:0000305}.
Tissue Specificity	Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes. {ECO:0000269|PubMed:11257134, ECO:0000269|PubMed:11337487}.
Top Pathways	Phagosome, Measles, Tuberculosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CD209 gene - orb90797 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Mouse DC-SIGN/CD209a (NP_573501) VersaClone cDNA - RDC0773 from R&D Systems Prices $199.00 Sizes 10 µg Species Mouse

Human DC-SIGN/CD209 (NP_066978) VersaClone cDNA - RDC1071 from R&D Systems Prices $199.00 Sizes 10 µg Species Human

CD209 - MBS1275328 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC110615

Human CD209/DC-SIGN Gene ORF cDNA clone in cloning vector - HG10200-M from Sino Biological Species Human

Human CD209/DC-SIGN Gene ORF cDNA clone expression plasmid - HG10200-UT from Sino Biological Species Human

Human CD209/DC-SIGN Gene ORF cDNA clone expression plasmid, C-HA tag - HG10200-CY from Sino Biological Species Human

Human CD209/DC-SIGN Gene ORF cDNA clone expression plasmid, C-His tag - HG10200-CH from Sino Biological Species Human

Human CD209/DC-SIGN Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10200-NF from Sino Biological Species Human

Human CD209/DC-SIGN Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10200-CF from Sino Biological Species Human

Human CD209/DC-SIGN Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10200-NM from Sino Biological Species Human

Human CD209/DC-SIGN Gene ORF cDNA clone expression plasmid, N-HA tag - HG10200-NY from Sino Biological Species Human

Human CD209/DC-SIGN Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10200-CM from Sino Biological Species Human

Human CD209/DC-SIGN Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10200-ACG from Sino Biological Species Human

Human CD209/DC-SIGN Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10200-ACR from Sino Biological Species Human

Human CD209/DC-SIGN Gene ORF cDNA clone expression plasmid, N-His tag - HG10200-NH from Sino Biological Species Human

Rhesus CD209/DC-SIGN Gene ORF cDNA clone expression plasmid, C-HA tag - CG90319-CY from Sino Biological Species Monkey

Rhesus CD209/DC-SIGN Gene ORF cDNA clone expression plasmid, C-Myc tag - CG90319-CM from Sino Biological Species Monkey

Rhesus CD209/DC-SIGN Gene ORF cDNA clone expression plasmid, N-His tag - CG90319-NH from Sino Biological Species Monkey

Rhesus CD209/DC-SIGN Gene ORF cDNA clone expression plasmid, C-His tag - CG90319-CH from Sino Biological Species Monkey

Rhesus CD209/DC-SIGN Gene ORF cDNA clone expression plasmid, N-HA tag - CG90319-NY from Sino Biological Species Monkey

Human CD209 ORF clone (NM_001144899.1) - CDCR044028 from Creative biogene Species Human

Human CD209 ORF clone (NM_001144897.1) - CDCR044030 from Creative biogene Species Human

Human CD209 ORF clone (NM_001144896.1) - CDCR044032 from Creative biogene Species Human

Human CD209 ORF clone (NM_001144895.1) - CDCR044034 from Creative biogene Species Human

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