| Gene Symbol | NFATC3 |
|---|---|
| Entrez Gene | 4775 |
| Alt Symbol | NFAT4, NFATX |
| Species | Human |
| Gene Type | protein-coding |
| Description | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 |
| Other Description | NF-ATc3|T cell transcription factor NFAT4|nuclear factor of activated T-cells c3 isoform IE-Xa|nuclear factor of activated T-cells, cytoplasmic 3 |
| Swissprots | O75211 Q99840 Q99842 Q14516 Q12968 Q99841 |
| Accessions | CAD88555 EAW83210 EAW83211 EAW83212 EAW83213 Q12968 AB209824 BAD93061 AK057574 AK290370 BAF83059 BC001050 AAH01050 BE350846 BU849493 CA418693 DQ895384 ABM86310 EU887605 ACG55625 EU887606 ACG55626 EU887607 ACG55627 EU887608 ACG55628 EU887609 ACG55629 EU887610 ACG55630 EU887611 ACG55631 EU887612 ACG55632 EU887613 ACG55633 EU887614 ACG55634 EU887615 ACG55635 EU887616 ACG55636 EU887617 ACG55637 EU887618 ACG55638 EU887619 ACG55639 EU887620 ACG55640 EU887621 ACG55641 EU887622 ACG55642 EU887623 ACG55643 EU887624 ACG55644 EU887625 ACG55645 L41067 AAA79174 U14510 AAA86308 U85428 AAB46595 U85429 AAB46596 U85430 AAB46597 NM_004555 NP_004546 NM_173163 NP_775186 NM_173165 NP_775188 NM_173164 |
| Function | Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2. {ECO:0000269|PubMed:18815128}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:18815128}. Nucleus {ECO:0000269|PubMed:18815128}. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. |
| Tissue Specificity | Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle. |
| Top Pathways | Wnt signaling pathway, HTLV-I infection, MAPK signaling pathway, B cell receptor signaling pathway, T cell receptor signaling pathway |