NFATC3

Gene Symbol NFATC3
Entrez Gene 4775
Alt Symbol NFAT4, NFATX
Species Human
Gene Type protein-coding
Description nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
Other Description NF-ATc3|T cell transcription factor NFAT4|nuclear factor of activated T-cells c3 isoform IE-Xa|nuclear factor of activated T-cells, cytoplasmic 3
Swissprots O75211 Q99840 Q99842 Q14516 Q12968 Q99841
Accessions CAD88555 EAW83210 EAW83211 EAW83212 EAW83213 Q12968 AB209824 BAD93061 AK057574 AK290370 BAF83059 BC001050 AAH01050 BE350846 BU849493 CA418693 DQ895384 ABM86310 EU887605 ACG55625 EU887606 ACG55626 EU887607 ACG55627 EU887608 ACG55628 EU887609 ACG55629 EU887610 ACG55630 EU887611 ACG55631 EU887612 ACG55632 EU887613 ACG55633 EU887614 ACG55634 EU887615 ACG55635 EU887616 ACG55636 EU887617 ACG55637 EU887618 ACG55638 EU887619 ACG55639 EU887620 ACG55640 EU887621 ACG55641 EU887622 ACG55642 EU887623 ACG55643 EU887624 ACG55644 EU887625 ACG55645 L41067 AAA79174 U14510 AAA86308 U85428 AAB46595 U85429 AAB46596 U85430 AAB46597 NM_004555 NP_004546 NM_173163 NP_775186 NM_173165 NP_775188 NM_173164
Function Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2. {ECO:0000269|PubMed:18815128}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:18815128}. Nucleus {ECO:0000269|PubMed:18815128}. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
Tissue Specificity Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle.
Top Pathways Wnt signaling pathway, HTLV-I infection, MAPK signaling pathway, B cell receptor signaling pathway, T cell receptor signaling pathway

NFATc3 CRISPR/Cas9 KO Plasmid (h) - sc-400339 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NFATc3 HDR Plasmid (h) - sc-400339-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NFATc3 Double Nickase Plasmid (h) - sc-400339-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NFATc3 Double Nickase Plasmid (h2) - sc-400339-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NFATc3 CRISPR Activation Plasmid (h) - sc-400339-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NFATc3 CRISPR Activation Plasmid (h2) - sc-400339-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NFATc3 Lentiviral Activation Particles (h) - sc-400339-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NFATc3 Lentiviral Activation Particles (h2) - sc-400339-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NFATc3 siRNA (h) - sc-29413 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NFATc3 shRNA Plasmid (h) - sc-29413-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NFATc3 shRNA (h) Lentiviral Particles - sc-29413-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NFATC3/NFAT4 RNAi - H00004775-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

NFATC3/NFAT4 RNAi - H00004775-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU151991 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15241 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05129 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05129

NFATC3 siRNA (Human) - CRH3168 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NFATC3/NFAT4 RNAi - H00004775-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

NFATC3/NFAT4 RNAi - H00004775-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human NFATC3 (NM_004555.3) - SHH351740 from Creative biogene

Category siRNA
Species Reactivities Human

Human NFATC3 siRNA - orb263670 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NFATC3 shRNA Plasmid (Human) - CHH3168 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NFATC3 miRNA 3'UTR clone - MiUTR3H-05237 from Creative biogene

Species Reactivities Human

NFATC3 miRNA 3'UTR clone - MiUTR3H-05238 from Creative biogene

Species Reactivities Human
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