| Gene Symbol |
SELPLG
|
| Entrez Gene |
6404
|
| Alt Symbol |
CD162, CLA, PSGL-1, PSGL1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
selectin P ligand
|
| Other Description |
P-selectin glycoprotein ligand 1|cutaneous lymphocyte-associated associated antigen
|
| Swissprots |
Q14242 J3KMX6 B7Z5C7 B4DQC3 Q6GTW7 Q8N7J7 A8K2Y0 Q12775
|
| Accessions |
AAA74577 AAP81163 CAG14915 CAG14916 EAW97824 EAW97825 Q14242 AK098315 BAC05283 AK127638 BAC87066 AK225644 AK290395 BAF83084 AK295238 BAG58231 AK298738 BAG60885 AK298742 BAH12863 AK300057 BAG61866 BC029782 AAH29782 CA427270 DC339004 DQ892117 ABM83043 DQ895313 ABM86239 U02297 AAC50061 XM_005269076 XP_005269133 NM_001206609 NP_001193538 NM_003006 NP_002997
|
| Function |
A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. {ECO:0000269|PubMed:11566773, ECO:0000269|PubMed:12403782}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Expressed on neutrophils, monocytes and most lymphocytes.
|
| Top Pathways |
Cell adhesion molecules (CAMs), Staphylococcus aureus infection
|