| Gene Symbol |
MCM8
|
| Entrez Gene |
84515
|
| Alt Symbol |
C20orf154, POF10, dJ967N21.5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
minichromosome maintenance complex component 8
|
| Other Description |
DNA helicase MCM8|DNA replication licensing factor MCM8|MCM8 minichromosome maintenance deficient 8|REC homolog
|
| Swissprots |
E7EQU7 B2RBG7 Q495R7 Q495R4 Q9UJA3 Q969I5 Q495R6 Q86US4 D3DW08
|
| Accessions |
CAL40366 CAL40367 CAL40368 CAL40369 CAL40371 CAL40372 EAX10403 EAX10404 EAX10405 Q9UJA3 AI200387 AJ439063 CAD27750 AK027644 BAB55260 AK297806 BAG60144 AK314654 BAG37214 AY158211 AAO21222 BC005170 BC008830 AAH08830 BC080656 AAH80656 BC101054 AAI01055 BC101055 AAI01056 BC101056 AAI01057 BC101057 AAI01058 BM664368 XM_011529387 XP_011527689 XR_937169 NM_001281520 NP_001268449 NM_001281521 NP_001268450 NM_001281522 NP_001268451 NM_032485 NP_115874 NM_182802 NP_877954
|
| Function |
Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8- MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. May also play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle. {ECO:0000269|PubMed:22771115}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12527764, ECO:0000269|PubMed:18072282}. Note=Localizes to nuclear foci and colocalizes with RAD51.
|
| Tissue Specificity |
Highest levels in placenta, lung and pancreas. Low levels in skeletal muscle and kidney. Expressed in various tumors with highest levels in colon and lung cancers. {ECO:0000269|PubMed:12771218}.
|