MCM8

Gene Symbol	MCM8
Entrez Gene	84515
Alt Symbol	C20orf154, POF10, dJ967N21.5
Species	Human
Gene Type	protein-coding
Description	minichromosome maintenance complex component 8
Other Description	DNA helicase MCM8|DNA replication licensing factor MCM8|MCM8 minichromosome maintenance deficient 8|REC homolog
Swissprots	E7EQU7 B2RBG7 Q495R7 Q495R4 Q9UJA3 Q969I5 Q495R6 Q86US4 D3DW08
Accessions	CAL40366 CAL40367 CAL40368 CAL40369 CAL40371 CAL40372 EAX10403 EAX10404 EAX10405 Q9UJA3 AI200387 AJ439063 CAD27750 AK027644 BAB55260 AK297806 BAG60144 AK314654 BAG37214 AY158211 AAO21222 BC005170 BC008830 AAH08830 BC080656 AAH80656 BC101054 AAI01055 BC101055 AAI01056 BC101056 AAI01057 BC101057 AAI01058 BM664368 XM_011529387 XP_011527689 XR_937169 NM_001281520 NP_001268449 NM_001281521 NP_001268450 NM_001281522 NP_001268451 NM_032485 NP_115874 NM_182802 NP_877954
Function	Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8- MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. May also play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle. {ECO:0000269|PubMed:22771115}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12527764, ECO:0000269|PubMed:18072282}. Note=Localizes to nuclear foci and colocalizes with RAD51.
Tissue Specificity	Highest levels in placenta, lung and pancreas. Low levels in skeletal muscle and kidney. Expressed in various tumors with highest levels in colon and lung cancers. {ECO:0000269|PubMed:12771218}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MCM8 protein fragment - ab164604 from Abcam Category Protein Source Wheat germ Species Human

MCM8 Antibody Blocking Peptide - LS-E5007 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MCM8 Antibody Blocking Peptide - LS-E13147 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MCM8 Antibody Blocking Peptide - LS-E13155 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MCM8 Antibody Blocking Peptide - LS-E13154 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MCM8 Antibody Blocking Peptide - LS-E13164 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MCM8 Protein - H00084515-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MCM8-Antibody-Center-Blocking-Peptide - BP17408c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MCM8 Blocking Peptide - 33R-4137 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MCM8 Blocking Peptide - 33R-2568 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MCM8 Blocking Peptide - 33R-7902 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MCM8 Blocking Peptide - 33R-2569 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MCM8 Blocking Peptide - abx064279 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine

MCM8 - H00084515-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MCM8 - H00084515-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MCM8 fusion protein - Ag8696 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

MCM8 fusion protein - ag8430 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human MCM8, GST-tagged - MCM8-782H from Creative Biomart Category Protein Source E.coli Species Human

MCM8 Blocking Peptide - CBP3085 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine

Recombinant Human DNA replication licensing factor MCM8(MCM8) ,partial - CSB-YP890907HU CSB-EP890907HU CSB-BP890907HU CSB-MP890907HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MCM8 Protein - abx163382 from Abbexa Category Protein Species Human, Mouse, Rat

MCM8 Peptide, Human - M34GP09320H from Creative Peptides Category Peptide Source Synthetic. Species Human

MCM8 Recombinant Protein Antigen - NBP2-55276PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DNA replication licensing factor MCM8 (MCM8), partial, Recombinant Protein - MBS1464396 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

MCM8 peptide - orb218948 from Biorbyt Category Peptide Species Human, Mouse, Rat

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