| Gene Symbol | Chst4 |
|---|---|
| Entrez Gene | 26887 |
| Alt Symbol | GST-3, Gn6st-2, HEC-GlcNAc6ST |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | carbohydrate (chondroitin 6/keratan) sulfotransferase 4 |
| Other Description | L-selectin ligand sulfotransferase|LSST|N-acetylglucosamine 6-O-sulfotransferase 2|carbohydrate sulfotransferase 4|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3|glcNAc6ST-2|high endothelial cell GlcNAC-6-sulphotransferase|high endothelial cells N-acetylglucosamine 6-O-sulfotransferase |
| Swissprots | Q9R1I1 Q9WUE5 |
| Accessions | AAD33016 EDL11448 EDL11449 Q9R1I1 AA672072 AF109155 AAD45579 AI614882 AK009113 BAB26078 BC057886 AAH57886 XM_006531043 XP_006531106 XM_006531044 XP_006531107 XM_006531045 XP_006531108 NM_011998 NP_036128 |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of SELL ligand sialyl 6-sulfo Lewis X on SELL counter-receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recognized by MECA-79 antibody. Plays a central role in lymphocyte trafficking during chronic inflammation. Has a catalytic preference for core 2-branched mucin-type O-glycans. Can use GlcNAcbeta1-6[Galbeta1-3]GalNAc-pNP (core 2), GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharide structures as acceptors. Has also activity toward core 3 of GlcNAcbeta1-3GalNAc-pNP. Its substrate specificity may be influenced by its subcellular loc |
| Subcellular Location | Golgi apparatus membrane {ECO:0000269|PubMed:15111310}; Single-pass type II membrane protein {ECO:0000269|PubMed:15111310}. |
| Tissue Specificity | Specifically expressed in HEV. {ECO:0000269|PubMed:10435581}. |
| Top Pathways | Glycosaminoglycan biosynthesis - keratan sulfate |