Chst4

Gene Symbol	Chst4
Entrez Gene	26887
Alt Symbol	GST-3, Gn6st-2, HEC-GlcNAc6ST
Species	Mouse
Gene Type	protein-coding
Description	carbohydrate (chondroitin 6/keratan) sulfotransferase 4
Other Description	L-selectin ligand sulfotransferase|LSST|N-acetylglucosamine 6-O-sulfotransferase 2|carbohydrate sulfotransferase 4|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3|glcNAc6ST-2|high endothelial cell GlcNAC-6-sulphotransferase|high endothelial cells N-acetylglucosamine 6-O-sulfotransferase
Swissprots	Q9R1I1 Q9WUE5
Accessions	AAD33016 EDL11448 EDL11449 Q9R1I1 AA672072 AF109155 AAD45579 AI614882 AK009113 BAB26078 BC057886 AAH57886 XM_006531043 XP_006531106 XM_006531044 XP_006531107 XM_006531045 XP_006531108 NM_011998 NP_036128
Function	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of SELL ligand sialyl 6-sulfo Lewis X on SELL counter-receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recognized by MECA-79 antibody. Plays a central role in lymphocyte trafficking during chronic inflammation. Has a catalytic preference for core 2-branched mucin-type O-glycans. Can use GlcNAcbeta1-6[Galbeta1-3]GalNAc-pNP (core 2), GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharide structures as acceptors. Has also activity toward core 3 of GlcNAcbeta1-3GalNAc-pNP. Its substrate specificity may be influenced by its subcellular loc
Subcellular Location	Golgi apparatus membrane {ECO:0000269|PubMed:15111310}; Single-pass type II membrane protein {ECO:0000269|PubMed:15111310}.
Tissue Specificity	Specifically expressed in HEV. {ECO:0000269|PubMed:10435581}.
Top Pathways	Glycosaminoglycan biosynthesis - keratan sulfate

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Recombinant Mouse CHST4, CF - 5547-ST-020 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Arg30-Gly388 with an N-terminal 6-His tag

Recombinant Mouse Carbohydrate sulfotransferase 4(Chst4) - CSB-YP886434MO CSB-EP886434MO CSB-BP886434MO CSB-MP886434MO from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Mouse

Recombinant Mouse CHST4 Protein, CF - 5547-ST from R&D Systems Category Protein Prices $329.00 Sizes 20 µg Source Chinese Hamster Ovary cell line, CHO-derived Arg30-Gly388 with an N-terminal 6-His tag Accession # Q9R1I1 Species Mouse

Carbohydrate sulfotransferase 4 (Chst4), Recombinant Protein - MBS1464093 from MyBioSource Category Protein Prices $1,160.00, $1,160.00, $1,390.00, $1,390.00, $1,855.00, $1,855.00, $2,315.00, $2,315.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Mouse

Recombinant Mouse CHST4 Protein - CHST4-3453M from Creative Biomart Category Protein Source Mammalian Cells Species Mouse

Glutathione S-transferase P 2 - PAT-83242-2 from Nordic BioSite Category Protein Species Mouse

Glutathione S-transferase P 2 - PAT-83242-1 from Nordic BioSite Category Protein Species Mouse

GSTP2 - PAT-83520-2 from Nordic BioSite Category Protein Species Mouse

GSTP2 - PAT-83520-1 from Nordic BioSite Category Protein Species Mouse

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