PAFAH1B1

Gene Symbol	PAFAH1B1
Entrez Gene	5048
Alt Symbol	LIS1, LIS2, MDCR, MDS, PAFAH
Species	Human
Gene Type	protein-coding
Description	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
Other Description	lissencephaly 1 protein|platelet-activating factor acetylhydrolase IB subunit alpha|platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit (45kD)|platelet-activating factor acetylhydrolase, isoform Ib, subunit 1 (45kDa)
Swissprots	Q8WZ89 B2R7Q7 Q8WZ88 P43034
Accessions	AAC51111 EAW90536 P43034 AF208835 AF208836 AF208837 AAL34972 AF208838 AAL34973 AF400434 AAK92483 AK293918 BAG57299 AK303015 BAG64145 AK313078 BAG35904 BC064638 AAH64638 BX538346 CAD98141 L13385 AAA02880 L13386 AAA02881 L13387 AAA02882 L13388 L25107 S81396 XM_011523901 XP_011522203 XM_011523902 XP_011522204 XM_011523903 XP_011522205 XM_011523904 XP_011522206 NM_000430 NP_000421
Function	Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration i
Subcellular Location	Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle {ECO:0000255|HAMAP- Rule:MF_03141}. Nucleus membrane {ECO:0000255|HAMAP- Rule:MF_03141}. Note=Redistributes to axons during neuronal development. Also localizes to the microtubules of the manchette in elongating spermatids and to the meiotic spindle in spermatocytes (By similarity). Localizes to the plus end of microtubules and to the centrosome. May localize to the nuclear membrane. {ECO:0000250}.
Tissue Specificity	Fairly ubiquitous expression in both the frontal and occipital areas of the brain.
Top Pathways	Ether lipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human LIS1 full length protein - ab131873 from Abcam Category Protein Source Wheat germ Species Human

Human LIS1 peptide - ab68597 from Abcam Category Peptide

Human LIS1 peptide - ab22930 from Abcam Category Peptide Species Human

Human LIS1 protein fragment - ab152587 from Abcam Category Protein Source Wheat germ Species Human

PAFAH1B1 / LIS1 Antibody Blocking Peptide - LS-E20316 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PAFAH1B1 / LIS1 Antibody Blocking Peptide - LS-E20315 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PAFAH1B1 / LIS1 Antibody Blocking Peptide - LS-E25360 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PAFAH1B1 / LIS1 Antibody Blocking Peptide - LS-E30373 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human LIS1 Protein - H00005048-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human LIS1 Protein - H00005048-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

LIS1 Blocking Peptide - NBP1-76815PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Goat anti PAFAH1B1 antibody Immunizing peptide - orb17686 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

PAFAH1B1 Blocking Peptide - 33R-4523 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PAFAH1B1 Blocking Peptide - 33R-6595 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PAFAH1B1 protein - 30R-3277 from Fitzgerald Category Protein Prices $210.00 Sizes 50 µg Source E.coli

LIS1 Peptide - AC21-0187-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PAFAH1B1 / LIS1 - H00005048-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PAFAH1B1 / LIS1 - H00005048-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PAFAH1B1 / LIS1 - H00005048-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PAFAH1B1 / LIS1 - H00005048-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PAFAH1B1 / LIS1 Control Peptide - AP30511CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

LIS1 Peptide - 4287P from ProSci Category Peptide Species Human

PAFAH1B1 Peptide - 45-104P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human, Rat

Recombinant Human Platelet-activating factor acetylhydrolase IB subunit alpha(PAFAH1B1) - CSB-YP017383HU CSB-EP017383HU CSB-BP017383HU CSB-MP017383HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

LIS1 (1-300) - sc-4510 WB from Santa Cruz Biotechnology Category Protein Prices $88.00 Sizes 10 µg/0.1 ml Species Human

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