Gene Symbol | WDR62 |
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Entrez Gene | 284403 |
Alt Symbol | C19orf14, MCPH2 |
Species | Human |
Gene Type | protein-coding |
Description | WD repeat domain 62 |
Other Description | WD repeat-containing protein 62|microcephaly, primary autosomal recessive 2 |
Swissprots | Q659D7 Q8NBF7 O43379 Q63HP9 Q96AD9 |
Accessions | AAC27979 O43379 AK090617 BAC03488 AL041673 AL117438 CAB55924 AL133651 CAH56390 AW029580 BC017261 AAH17261 BC058939 BC128417 AAI28418 BC151839 BQ880028 BQ960310 BU508347 BX647726 CAH56191 CF142643 JF432250 ADZ15467 XM_005258809 XP_005258866 XM_011526837 XP_011525139 XM_011526838 XP_011525140 XM_011526839 XP_011525141 XM_011526840 XP_011525142 XM_011526841 XP_011525143 XM_011526842 XP_011525144 XM_011526843 XP_011525145 XM_011526844 XP_011525146 NM_001083961 NP_001077430 NM_173636 NP_775907 |
Function | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration. {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278}. |
Subcellular Location | Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Shows cell cycle-dependent localization. Accumulates to the spindle pole during mitosis. |
Tissue Specificity | Present in fetal brain, enriched within the ventricular and subventricular zone (at protein level). In the embryonic brain it is expressed in mitotic neural precursor cells. {ECO:0000269|PubMed:20890279}. |
WDR62 CRISPR/Cas9 KO Plasmid (h) - sc-410410 from Santa Cruz Biotechnology
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WDR62 HDR Plasmid (h) - sc-410410-HDR from Santa Cruz Biotechnology
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WDR62 Double Nickase Plasmid (h) - sc-410410-NIC from Santa Cruz Biotechnology
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WDR62 Double Nickase Plasmid (h2) - sc-410410-NIC-2 from Santa Cruz Biotechnology
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WDR62 CRISPR Activation Plasmid (h) - sc-410410-ACT from Santa Cruz Biotechnology
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WDR62 CRISPR Activation Plasmid (h2) - sc-410410-ACT-2 from Santa Cruz Biotechnology
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WDR62 Lentiviral Activation Particles (h) - sc-410410-LAC from Santa Cruz Biotechnology
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WDR62 Lentiviral Activation Particles (h2) - sc-410410-LAC-2 from Santa Cruz Biotechnology
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WDR62 siRNA (h) - sc-97678 from Santa Cruz Biotechnology
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WDR62 shRNA Plasmid (h) - sc-97678-SH from Santa Cruz Biotechnology
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WDR62 shRNA (h) Lentiviral Particles - sc-97678-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU158281 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22844 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22844 from Sigma-Aldrich
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WDR62 siRNA (Human) - CRJ7019 from Cohesion Biosciences
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WDR62 - MBS8208418 from MyBioSource
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shRNA set against Human WDR62(NM_173636.4) - SHL123574 from Creative biogene
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Human WDR62 siRNA - orb277520 from Biorbyt
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WDR62 shRNA Plasmid (Human) - CHJ7019 from Cohesion Biosciences
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WDR62 miRNA 3'UTR clone - MiUTR1H-11230 from Creative biogene
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WDR62 miRNA 3'UTR clone - MiUTR3H-12958 from Creative biogene
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