PILRA

Gene Symbol PILRA
Entrez Gene 29992
Alt Symbol FDF03
Species Human
Gene Type protein-coding
Description paired immunoglobin-like type 2 receptor alpha
Other Description cell surface receptor FDF03|inhibitory receptor PILR-alpha|paired immunoglobulin-like type 2 receptor alpha
Swissprots Q9UKJ1 Q8NHI1
Accessions EAL23835 EAL23836 EAL23837 EAW76542 EAW76543 EAW76544 EAW76545 Q9UKJ1 AF161080 AAD52964 AJ400841 CAC01613 AJ400842 CAC01614 AJ400843 CAC01615 AK298731 BAG60881 BC017812 AAH17812 BF432841 NM_013439 NP_038467 NM_178272 NP_840056 NM_178273 NP_840057
Function Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. {ECO:0000269|PubMed:10903717, ECO:0000269|PubMed:18358807, ECO:0000269|PubMed:21241660}.
Subcellular Location Isoform 3: Secreted {ECO:0000305}.
Tissue Specificity Predominantly detected in hemopoietic tissues and is expressed by monocytes, macrophages, and granulocytes, but not by lymphocytes. Also strongly expressed by dendritic cells (DC); preferentially by CD14+/CD1a- DC derived from CD34+ progenitors. Also expressed by CD11c+ blood and tonsil DC, but not by CD11c- DC precursors. {ECO:0000269|PubMed:10903717}.
Top Pathways Herpes simplex infection

PILR-α (K-13) - sc-104616 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PILR-α (K-13): sc-104616. Western blot analysis of PILR-α expression in THP-1 (A), HL-60 (B) and CCRF-CEM (C) nuclear extracts.

PILR-α (A-15) - sc-104613 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PILR-α (47-12) - sc-100286 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
PILR-α (47-12): sc-100286. Western blot analysis of PILR-α expression in HeLa nuclear extract.

Anti-PILRA antibody - ab105605 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PILRA antibody (ab105605) at 0.5 µg/ml + HepG2 cell lysate at 10 µg

Anti-PILRA Antibody - LS-C144094 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-PILRA Antibody (aa21-197) - LS-C74028 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-PILRA Antibody (aa20-196) - LS-C184866 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-PILRA Antibody (aa1-227, Azide-free) - LS-C328129 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-PILRA Antibody (aa51-100) - LS-C80964 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 15%.

PILR-alpha Antibody (462415) - MAB6484 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 462415
Western blot shows lysates of THP‑1 human acute monocytic leukemia cell line. PVDF Membrane was probed with 2 µg/mL of Human PILR‑ alpha Monoclonal Antibody (Catalog # MAB6484) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for PILR‑ alpha at approximately 30 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

PILR-alpha Antibody - AF4318 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
J774A.1 mouse reticulum cell sarcoma macrophage cell line was stained with Goat Anti-Mouse PILR‑ alpha Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4318, filled histogram) or control antibody (Catalog # AB‑108‑C, open histogram), followed by Phycoerythrin-conjugated Anti-Goat IgG Secondary Antibody (Catalog # F0107).

PILR-alpha Antibody - AF6484 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Human peripheral blood granulocytes were stained with Sheep Anti-Human PILR‑ alpha Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6484, filled histogram) or control antibody (Catalog # 5‑001‑A, open histogram), followed by NorthernLights™ 637-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # NL011).

PILR-alpha Antibody - NBP2-13763 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: PILRA Antibody [NBP2-13763] Staining of human bronchus shows strong cytoplasmic positivity in respiratory epithelial cells.

PILR-alpha Antibody - NBP1-60095 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

PILR-alpha Antibody (36H2) - DDX0230P-100 from Novus Biologicals

Prices $279.00, $369.00
Sizes 50 µg, 100 µg
Host Rat
Clonality Monoclonal
Clone 36H2
Western Blot: PILR-alpha Antibody (36H2) [DDX0230P-100] - FDFO3 is a cell-surface monomericglycoprotein

PILR-alpha Antibody (3C2) - H00029992-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3C2

PILR-alpha Antibody [Allophycocyanin] - FAB6484A from Novus Biologicals

Prices $339.00
Sizes 100 tests
Host Sheep
Clonality Polyclonal
Human peripheral blood granulocytes were stained with Sheep Anti-Human PILR-a APC-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB6484A, filled histogram) or isotype control antibody (Catalog # IC016A, open histogram). View our protocol for Staining Membrane-associated Proteins.

PILR-alpha Antibody [Alexa Fluor (R) 488] - FAB6484G from Novus Biologicals

Host Sheep
Clonality Polyclonal

PILR-alpha Antibody [PE] - FAB6484P from Novus Biologicals

Host Sheep
Clonality Polyclonal

PILR-alpha Antibody [Phycoerythrin] - FAB4318P from Novus Biologicals

Prices $289.00
Sizes 100 tests
Host Goat
Clonality Polyclonal
J774A.1 mouse reticulum cell sarcoma macrophage cell line was stained with Goat Anti-Mouse PILR-a PE-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB4318P, filled histogram) or isotype control antibody (Catalog # IC108P, open histogram). View our protocol for Staining Membrane-associated Proteins.

PILR-alpha Antibody (36H2) [Biotin] - DDX0230B-100 from Novus Biologicals

Host Rat
Clonality Monoclonal
Clone 36H2

PILR-alpha Antibody (36H2) [Alexa Fluor (R) 647] - DDX0230A647-100 from Novus Biologicals

Host Rat
Clonality Monoclonal
Clone 36H2

PILR-alpha Antibody (36H2) [Alexa Fluor (R) 546] - DDX0230A546-100 from Novus Biologicals

Host Rat
Clonality Monoclonal
Clone 36H2

PILR-alpha Antibody (36H2) [Alexa Fluor (R) 488] - DDX0230A488-100 from Novus Biologicals

Host Rat
Clonality Monoclonal
Clone 36H2

PILR beta Polyclonal Antibody - bs-2690R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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