| Gene Symbol | ACKR4 |
|---|---|
| Entrez Gene | 51554 |
| Alt Symbol | CC-CKR-11, CCBP2, CCR-11, CCR10, CCR11, CCRL1, CCX CKR, CCX-CKR, CKR-11, PPR1, VSHK1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | atypical chemokine receptor 4 |
| Other Description | C-C CKR-11|C-C chemokine receptor type 11|CC chemokine receptor-like 1|chemocentryx chemokine receptor|chemokine (C-C motif) receptor-like 1|chemokine, cc motif, receptor-like protein 1|orphan seven-transmembrane receptor, chemokine related |
| Swissprots | B2R9U7 Q9NPB9 |
| Accessions | AAF44751 AAF61299 AAO65972 CBJ18620 Q9NPB9 AF110640 AAF59827 AK225927 AK304461 BAG65277 AK313923 BAG36644 BC069438 AAH69438 BC095501 AAH95501 BQ015927 DC419249 NM_016557 NP_057641 NM_178445 NP_848540 |
| Function | Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus. {ECO:0000269|PubMed:10706668, ECO:0000269|PubMed:23121557, ECO:0000269|PubMed:23341447}. |
| Subcellular Location | Early endosome {ECO:0000269|PubMed:23341447}. Recycling endosome {ECO:0000269|PubMed:23341447}. Cell membrane {ECO:0000269|PubMed:23341447}; Multi-pass membrane protein {ECO:0000269|PubMed:23341447}. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane. |
| Tissue Specificity | Predominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine. {ECO:0000269|PubMed:10734104, ECO:0000269|PubMed:10767544, ECO:0000269|PubMed:11981810}. |