ACKR4

Gene Symbol ACKR4
Entrez Gene 51554
Alt Symbol CC-CKR-11, CCBP2, CCR-11, CCR10, CCR11, CCRL1, CCX CKR, CCX-CKR, CKR-11, PPR1, VSHK1
Species Human
Gene Type protein-coding
Description atypical chemokine receptor 4
Other Description C-C CKR-11|C-C chemokine receptor type 11|CC chemokine receptor-like 1|chemocentryx chemokine receptor|chemokine (C-C motif) receptor-like 1|chemokine, cc motif, receptor-like protein 1|orphan seven-transmembrane receptor, chemokine related
Swissprots B2R9U7 Q9NPB9
Accessions AAF44751 AAF61299 AAO65972 CBJ18620 Q9NPB9 AF110640 AAF59827 AK225927 AK304461 BAG65277 AK313923 BAG36644 BC069438 AAH69438 BC095501 AAH95501 BQ015927 DC419249 NM_016557 NP_057641 NM_178445 NP_848540
Function Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus. {ECO:0000269|PubMed:10706668, ECO:0000269|PubMed:23121557, ECO:0000269|PubMed:23341447}.
Subcellular Location Early endosome {ECO:0000269|PubMed:23341447}. Recycling endosome {ECO:0000269|PubMed:23341447}. Cell membrane {ECO:0000269|PubMed:23341447}; Multi-pass membrane protein {ECO:0000269|PubMed:23341447}. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
Tissue Specificity Predominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine. {ECO:0000269|PubMed:10734104, ECO:0000269|PubMed:10767544, ECO:0000269|PubMed:11981810}.

CCXCKR (C-16) - sc-46835 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CCXCKR (C-16): sc-46835. Western blot analysis of CCXCKR expression in mouse heart tissue extract.

CCXCKR (N-12) - sc-46836 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CCR11 antibody - ab1660 from Abcam

Prices $380.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Immunohistochemistry using ab1660 on human lung tissue section

Anti-CCR11 antibody - ab74806 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab74806 at 1/500 dilution staining CCR11 in MCF7 cells by Immunofluorescence, in the absence or presence of the immunising peptide.

Anti-CCR11 antibody - ab136040 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CCR11 antibody (ab136040) at 1/500 dilution + HepG2 cell lysate

Anti-CCR11 antibody [E100] - ab32564 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone E100
Anti-CCR11 antibody [E100] (ab32564) at 1/10000 dilution + K562 cell lysate

Anti-CCR11 antibody - Cytoplasmic domain - ab140787 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed, paraffin embedded Human heart tissue labelling CCR11 with ab140787 at 32 µg/ml.

Anti-CCR11 antibody - N-terminal - ab199664 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CCR11 antibody - N-terminal (ab199664) at 1/1000 dilutionLane 1 : HepG2 cell lysateLane 2 : K562 cell lysateLysates/proteins at 35 µg per lane.SecondaryGoat anti-rabbit IgG H&L(HRP) at 1/5000 dilution

Anti-ACKR4 / CCRL1 / CCR11 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A1441 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CCRL1 antibody LS-A1441 IHC of human heart, cardiac myocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-ACKR4 / CCRL1 / CCR11 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A1442 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CCRL1 / CCR11 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-A1442 dilution 24-32 ug/ml.

Anti-ACKR4 / CCRL1 / CCR11 Antibody - LS-C12626 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-ACKR4 / CCRL1 / CCR11 Antibody (aa4-31) - LS-C83957 from LifeSpan Bioscience

Prices $455.00
Sizes 200 µg
Host Goat
Clonality Polyclonal
IHC of CCRL1 / CCR11 antibody LS-C83957. Formalin-fixed, paraffin-embedded mouse lung.

Anti-ACKR4 / CCRL1 / CCR11 Antibody (C-Terminus) - LS-C145358 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CCRL1 antibody LS-C145358 Western blot of 721_B Cell lysate. Antibody concentration 1 ug/ml.

Anti-ACKR4 / CCRL1 / CCR11 Antibody (C-Terminus) - LS-C145677 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CCRL1 antibody LS-C145677 Western blot of 293T Cell lysate. Antibody concentration 1 ug/ml.

Anti-ACKR4 / CCRL1 / CCR11 Antibody (Extracellular Domain, clone E100) - LS-C50050 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone E100
Western blot analysis on K562 cell lysate using anti-CKRB/CKR11 (N-term) antibody; dilution 1:10000.

Anti-ACKR4 / CCRL1 / CCR11 Antibody (aa291-340) - LS-C119433 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of MCF7 cells, using CCRL1 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-ACKR4 / CCRL1 / CCR11 Antibody (aa5-54) - LS-C120559 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of COS7 cells, using CCRL1 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-ACKR4 / CCRL1 / CCR11 Antibody (aa47-96) - LS-C291762 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

CCR11 Antibody - NBP1-79925 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CCR11 Antibody [NBP1-79925] - 293T cell Lysate, concentration 1ug/ml.

CCR10/GPR2 Antibody - NB100-707 from Novus Biologicals

Prices $279.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Immunohistochemistry: CCR10/GPR2 Antibody [NB100-707] - Paraffin sections of human spleen.

CCR11 Antibody - NB100-705 from Novus Biologicals

Prices $279.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Immunohistochemistry-Paraffin: CCR11 Antibody [NB100-705] - Immunohistochemistry with antibody to human CCR11 on paraffin section of human lung.

CCR11 Antibody (674144) [Unconjugated] - MAB6899 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 674144
HEK293 human embryonic kidney cell line transfected with either (A) human CCR11 or (B) irrelevant transfectants and eGFP was stained with Mouse Anti-Human CCR11 Monoclonal Antibody (Catalog # MAB6899) followed by Allophycocyanin-conjugated Anti-Mouse IgM Secondary Antibody (Catalog # F0117). Quadrant markers were set based on control antibody staining. View our protocol for Staining Membrane-associated Proteins.

CC Chemokine Receptor D6 Antibody - NBP1-88150 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CC Chemokine Receptor D6 Antibody [NBP1-88150] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

CC Chemokine Receptor D6 Antibody - NBP1-00751 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: CC Chemokine Receptor D6 Antibody [NBP1-00751] - Western blot (WB) analysis of CC Chemokine Receptor D6 (S383) antibody in extracts from HepG2

CCR10/GPR2 Antibody - NLS1152 from Novus Biologicals

Prices $329.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: CCR10/GPR2 Antibody [NLS1152] - Anti-CCR10 / GPR2 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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