| Gene Symbol |
ORC3
|
| Entrez Gene |
23595
|
| Alt Symbol |
LAT, LATHEO, ORC3L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
origin recognition complex, subunit 3
|
| Other Description |
homolog of latheo, Drosophila|origin recognition complex subunit 3|origin recognition complex subunit Latheo|origin recognition complex, subunit 3 honolog
|
| Swissprots |
Q6IUY7 Q5T159 Q53GY6 A2A2T5 Q9UNT6 Q9UG44 Q13565 Q86TN5 Q9UBD5 B4E025
|
| Accessions |
AAT38109 EAW48581 EAW48582 EAW48583 Q9UBD5 AF093535 AAD40220 AF125507 AAD18057 AF135044 AAD30282 AK094135 AK222795 BAD96515 AK302750 BAG63963 AK303056 BAH13891 AK303182 BAG64276 AK303195 BAG64287 AK315911 BAH14282 AK316298 BAH14669 AL080116 CAB45715 BC035494 AAH35494 BC047689 AAH47689 BF215571 BM971022 CR456814 CAG33095 DC395106 EU446990 ABZ92519 EU831634 ACE87234 U50950 AAA96313 XM_005248704 XP_005248761 XM_005248705 XP_005248762 XM_005248706 XP_005248763 XM_011535651 XP_011533953 XM_011535652 XP_011533954 XR_942370 NM_001197259 NP_001184188 NM_012381 NP_036513 NM_181837 NP_862820
|
| Function |
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. {ECO:0000269|PubMed:22427655}.
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
Cell cycle
|
![Western Blot: ORC3L Overexpression Lysate (Adult Normal) [NBP2-10357] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ORC3L.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10028_ORC3L%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10357-img0001.jpg)