| Gene Symbol |
CDCA7
|
| Entrez Gene |
83879
|
| Alt Symbol |
JPO1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cell division cycle associated 7
|
| Other Description |
c-Myc target JPO1|cell division cycle associated protein 7|cell division cycle-associated protein 7
|
| Swissprots |
Q9BWT1 Q96BV8 Q8NBY9 Q658K4 Q96SP5 Q53EW5 B4DV66 Q580W9 B4DLP8 Q658N4
|
| Accessions |
AAX82003 EAX11158 EAX11159 EAX11160 EAX11161 Q9BWT1 AK027628 BAB55245 AK027642 BAB55258 AK075134 BAC11425 AK223524 BAD97244 AK297097 BAG59610 AK297245 BAG59725 AK300949 BAG62578 AL833728 CAH56253 AL834186 CAH56357 AY029179 AAK31591 BC015124 AAH15124 BC027966 AAH27966 DA531905 HQ447803 ADQ32287 XM_011511957 XP_011510259 XR_923034 NM_031942 NP_114148 NM_145810 NP_665809
|
| Function |
Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator. {ECO:0000269|PubMed:11598121, ECO:0000269|PubMed:15994934, ECO:0000269|PubMed:16580749, ECO:0000269|PubMed:23166294}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Predominantly nuclear with some expression also seen in the cytoplasm. Predominantly cytoplasmic when phosphorylated at Thr-163.
|
| Tissue Specificity |
Ubiquitous with higher level in thymus and small intestine. Overexpressed in a large number of tumors, in blood from patients with acute myelogenous leukemia (AML) and in chronic myelogenous leukemia (CML) blast crisis. {ECO:0000269|PubMed:11598121, ECO:0000269|PubMed:15994934}.
|