| Gene Symbol |
PPIH
|
| Entrez Gene |
10465
|
| Alt Symbol |
CYP-20, CYPH, SnuCyp-20, USA-CYP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
peptidylprolyl isomerase H (cyclophilin H)
|
| Other Description |
PPIase h|U-snRNP-associated cyclophilin SnuCyp-20|U-snRNP-associated cyclophilin SunCyp-20|USA-CyP SnuCyp-20|cyclophilin H|peptidyl-prolyl cis-trans isomerase H|rotamase H|small nuclear ribonucleoprotein particle-specific cyclophilin H
|
| Swissprots |
O43447 A6NNE7
|
| Accessions |
EAX07151 EAX07152 EAX07153 EAX07154 EAX07155 EAX07156 O43447 AF016371 AAC51927 AF036331 AAC60793 AF086102 AK294288 BAH11725 AK309438 AK310052 AK311979 BAG34918 BC003412 AAH03412 BT019343 AAV38150 BU955702 CR541899 CAG46697 CR541920 CAG46718 DQ890971 ABM81897 DQ894146 ABM85072 HG491950 XM_005270362 XP_005270419 XM_005270366 XP_005270423 XM_011540508 XP_011538810 XR_426585 XR_946523 XR_946524 XR_946525 NM_006347 NP_006338
|
| Function |
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone. {ECO:0000269|PubMed:11823439, ECO:0000269|PubMed:12875835, ECO:0000269|PubMed:9570313}.
|
| Subcellular Location |
Nucleus speckle {ECO:0000269|PubMed:9570313}. Cytoplasm {ECO:0000269|PubMed:9570313}. Note=Colocalizes with spliceosomal snRNPs. A small proportion may also be cytoplasmic.
|
| Top Pathways |
Spliceosome
|
![Western Blot: PPIH Overexpression Lysate (Adult Normal) [NBL1-14650] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PPIH.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6610_PPIH%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14650-img0002.jpg)