| Gene Symbol |
ILKAP
|
| Entrez Gene |
80895
|
| Alt Symbol |
ILKAP2, ILKAP3, PP2C-DELTA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
integrin-linked kinase-associated serine/threonine phosphatase
|
| Other Description |
integrin-linked kinase associated phosphatase|integrin-linked kinase-associated serine/threonine phosphatase 2C|protein phosphatase 2c, delta isozyme
|
| Swissprots |
Q9H0C8 B3KM39
|
| Accessions |
AAY24336 EAW71145 EAW71146 Q9H0C8 AK001043 BAG50851 AK055417 AL136850 CAB66784 AY024365 AAK07736 BC006576 AAH06576 BC035746 BC050422 CR533533 CAG38564 DQ892800 ABM83726 DQ896047 ABM87046 EU832279 ACE87536 EU832364 ACE86849 FJ491380 ACL54845 FJ491381 ACL54846 HQ658059 AEI30977 HQ658060 AEI30978 XM_005246106 XP_005246163 XM_006712784 XP_006712847 XM_011511946 XP_011510248 XR_923033 NM_030768 NP_110395 NM_176799
|
| Function |
Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation. {ECO:0000269|PubMed:14990992}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11331582}.
|
| Tissue Specificity |
Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues. {ECO:0000269|PubMed:11331582}.
|