DUT

Gene Symbol	DUT
Entrez Gene	1854
Alt Symbol	dUTPase
Species	Human
Gene Type	protein-coding
Description	deoxyuridine triphosphatase
Other Description	dUTP diphosphatase|dUTP nucleotidohydrolase|dUTP pyrophosphatase|deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Swissprots	Q6NSA3 Q16860 Q16708 Q6FHN1 A8K650 P33316 B4DPR5 O14785 Q96Q81
Accessions	AAB71393 AAB71394 AAB93866 AAB93867 AAX14045 EAW77349 EAW77350 EAW77351 EAW77352 P33316 AB049113 BAB13724 AK000629 AK291515 BAF84204 AK298464 BAG60677 AK312122 BAG35058 BC033645 AAH33645 BC070339 AAH70339 BC110377 AAI10378 BF697257 BG505144 BG532018 BI257870 CR541720 CAG46521 CR541781 CAG46580 DQ891191 ABM82117 DQ894375 ABM85301 L11877 AAA36801 M89913 AAA58444 U31930 AAC50418 U62891 AAC51123 U90223 AAB94642 XM_011521315 XP_011519617 XR_931760 NM_001025248 NP_001020419 NM_001025249 NP_001020420 NM_001948 NP_001939
Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. {ECO:0000269|PubMed:8805593}.
Subcellular Location	Isoform 2: Nucleus.
Tissue Specificity	Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with the cessation of nuclear DNA replication (at protein level). {ECO:0000269|PubMed:9228092}.
Top Pathways	Pyrimidine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

dUTPase CRISPR/Cas9 KO Plasmid (h) - sc-405843 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

dUTPase HDR Plasmid (h) - sc-405843-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

dUTPase Double Nickase Plasmid (h) - sc-405843-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

dUTPase Double Nickase Plasmid (h2) - sc-405843-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

dUTPase CRISPR Activation Plasmid (h) - sc-405843-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

dUTPase CRISPR Activation Plasmid (h2) - sc-405843-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

dUTPase Lentiviral Activation Particles (h) - sc-405843-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

dUTPase Lentiviral Activation Particles (h2) - sc-405843-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

dUTPase siRNA (h) - sc-62242 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

dUTPase shRNA Plasmid (h) - sc-62242-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

dUTPase shRNA (h) Lentiviral Particles - sc-62242-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

dUTPase RNAi - H00001854-R06 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

dUTPase RNAi - H00001854-R05 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU119721 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® Human Phosphatase - SIHP0155 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0949 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0156 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0154 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

CompoZr® Knockout ZFN Kit - CKOZFN7563 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7563 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

DUT siRNA (Human) - CRH1300 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

dUTPase RNAi - H00001854-R04 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol

DUT - MBS8238311 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

dUTPase CRISPR/Cas9 KO Plasmid (h2) - sc-405843-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

dUTPase HDR Plasmid (h2) - sc-405843-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

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