| Gene Symbol |
Aadat
|
| Entrez Gene |
23923
|
| Alt Symbol |
AI875679, Aadt, KATII, Kat2, mKat-2
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
aminoadipate aminotransferase
|
| Other Description |
2-aminoadipate aminotransferase|2-aminoadipate transaminase|KAT/AadAT|alpha-aminoadipate aminotransferase|kynurenine aminotransferase II|kynurenine--oxoglutarate aminotransferase II|kynurenine--oxoglutarate transaminase 2|kynurenine--oxoglutarate transaminase II|kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
|
| Swissprots |
Q9WVM8
|
| Accessions |
EDL28634 Q9WVM8 AF072376 AAD39680 AK075578 BAC35833 AK144042 BAE25669 BC012637 AAH12637 XM_006509397 XP_006509460 XM_011242215 XP_011240517 NM_011834 NP_035964
|
| Function |
Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino- group acceptors, with a preference for 2-oxoglutarate, 2- oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro) (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Mitochondrion {ECO:0000305}.
|
| Tissue Specificity |
Expressed mainly in kidney and to a lesser amount in liver and brain. {ECO:0000269|PubMed:10441733}.
|
| Top Pathways |
Lysine degradation, Tryptophan metabolism, Lysine biosynthesis, Biosynthesis of amino acids, 2-Oxocarboxylic acid metabolism
|