AP1G2
| Gene Symbol | AP1G2 |
|---|---|
| Entrez Gene | 8906 |
| Alt Symbol | G2AD |
| Species | Human |
| Gene Type | protein-coding |
| Description | adaptor-related protein complex 1, gamma 2 subunit |
| Other Description | AP-1 complex subunit gamma-like 2|clathrin-associated/assembly/adaptor protein, large, gamma-2|gamma2-adaptin |
| Swissprots | D3DS51 O75843 O75504 |
| Accessions | CCQ43243 EAW66132 EAW66134 EAW66138 O75843 AB015318 BAA33390 AF068706 AAC67390 AI497879 AK096034 AK123354 AK226158 AK304682 BAG65453 AK307696 AK309103 AK310451 AW451370 BC051833 AAH51833 BG701521 BI918958 BQ073124 BX161425 CAD61898 BX247963 CAD62302 H41406 XM_005268167 XP_005268224 XM_005268168 XP_005268225 XM_005268169 XP_005268226 XM_005268170 XP_005268227 XM_005268172 XP_005268229 XM_005268173 XP_005268230 XM_005268174 XP_005268231 XM_005268175 XP_005268232 XM_005268177 XP_005268234 XM_005268178 XP_005268235 XM_005268179 XP_005268236 XM_005268180 XP_005268237 XM_005268181 XP_005268238 XM_005268182 XP_005268239 XM_006720301 XP_006720364 XM_011537282 XP_011535584 XM_011537283 XP_011535585 XM_011537284 XP_011535586 XM_011537285 XP_011535587 XM_011537286 XP_011535588 XR_943550 XR_943551 XR_943552 XR_943553 XR_943554 XR_943555 NM_001282474 NP_001269403 NM_001282475 NP_001269404 NM_003917 NP_003908 NM_080545 |
| Function | May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV). {ECO:0000269|PubMed:16867982, ECO:0000269|PubMed:17553870, ECO:0000269|PubMed:9733768}. |
| Subcellular Location | Golgi apparatus membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Mainly localized to perinuclear vesicular structures. Colocalizes with HBV major surface antigen L and HBV core protein C in CD63-containing compartments. Colocalizes with HBV major surface antigen L to cis-Golgi-like structures. |
| Tissue Specificity | Expressed in all but one (skeletal muscle) tissues examined. |
| Top Pathways | Lysosome |
γ2-Adaptin CRISPR/Cas9 KO Plasmid (h) - sc-411225 from Santa Cruz Biotechnology
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γ2-Adaptin HDR Plasmid (h) - sc-411225-HDR from Santa Cruz Biotechnology
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γ2-Adaptin Double Nickase Plasmid (h) - sc-411225-NIC from Santa Cruz Biotechnology
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γ2-Adaptin Double Nickase Plasmid (h2) - sc-411225-NIC-2 from Santa Cruz Biotechnology
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γ2-Adaptin CRISPR Activation Plasmid (h) - sc-411225-ACT from Santa Cruz Biotechnology
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γ2-Adaptin CRISPR Activation Plasmid (h2) - sc-411225-ACT-2 from Santa Cruz Biotechnology
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γ2-Adaptin Lentiviral Activation Particles (h) - sc-411225-LAC from Santa Cruz Biotechnology
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γ2-Adaptin Lentiviral Activation Particles (h2) - sc-411225-LAC-2 from Santa Cruz Biotechnology
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γ2-Adaptin siRNA (h) - sc-92376 from Santa Cruz Biotechnology
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γ2-Adaptin shRNA Plasmid (h) - sc-92376-SH from Santa Cruz Biotechnology
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γ2-Adaptin shRNA (h) Lentiviral Particles - sc-92376-V from Santa Cruz Biotechnology
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AP1G2 RNAi - H00008906-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN3281 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3281 from Sigma-Aldrich
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AP1G2 siRNA (Human) - CRH5888 from Cohesion Biosciences
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AP1G2 RNAi - H00008906-R02 from Novus Biologicals
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AP1G2 - MBS8223353 from MyBioSource
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shRNA set against Human AP1G2 (NM_003917.2) - SHH237758 from Creative biogene
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Human AP1G2 siRNA - orb266390 from Biorbyt
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AP1G2 shRNA Plasmid (Human) - CHH5888 from Cohesion Biosciences
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AP1G2 miRNA 3'UTR clone - MiUTR1H-00435 from Creative biogene
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