NMNAT1

Gene Symbol	NMNAT1
Entrez Gene	64802
Alt Symbol	LCA9, NMNAT, PNAT1
Species	Human
Gene Type	protein-coding
Description	nicotinamide nucleotide adenylyltransferase 1
Other Description	NMN adenylyltransferase 1|NMN/NaMN adenylyltransferase 1|NaMN adenylyltransferase 1|nicotinamide mononucleotide adenylyltransferase 1|nicotinamide-nucleotide adenylyltransferase 1|nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1|nicotinate-nucleotide adenylyltransferase 1|pyridine nucleotide adenylyltransferase 1
Swissprots	Q9H247 Q9HAN9 Q9H6B6 Q8TAE9 B1AN63
Accessions	AAL76935 CAK32267 CAM12697 CDH92521 EAW71635 EAW71636 Q9HAN9 AF088049 AF312734 AAG33629 AF314163 AAG33632 AF459819 AAL76934 AI247931 AK026065 BAB15345 AK222920 BAD96640 AK315640 BAG38007 BC014943 AAH14943 BC032483 BG751629 BP309588 BP339298 BU948893 HG491681 JF432503 ADZ15720 XM_011541971 XP_011540273 NM_001297778 NP_001284707 NM_001297779 NP_001284708 NM_022787 NP_073624
Function	Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following mechanical or toxic insults. {ECO:0000269|PubMed:17402747}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:11248244, ECO:0000269|PubMed:12574164, ECO:0000269|PubMed:16118205, ECO:0000269|PubMed:22842230}.
Tissue Specificity	Widely expressed with highest levels in skeletal muscle, heart and kidney. Also expressed in the liver pancreas and placenta. Widely expressed throughout the brain. {ECO:0000269|PubMed:11027696, ECO:0000269|PubMed:11891043}.
Top Pathways	Nicotinate and nicotinamide metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Nmnat1 full length protein - ab198473 from Abcam Category Protein Prices $911.00 Sizes 100 µg Source E. coli Species Human

Active human Nmnat1 full length protein - ab190846 from Abcam Category Protein Prices $235.00 Sizes 10 µg Source E. coli Species Human

Human Nmnat1 full length protein - ab108957 from Abcam Category Protein Source E. coli Species Human

Human Nmnat1 peptide - ab45547 from Abcam Category Peptide

Human Nmnat1 peptide - ab101734 from Abcam Category Peptide

NMNAT-1 Partial Recombinant Protein - H00064802-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

NMNAT-1 Recombinant Protein - H00064802-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human NMNAT-1 Protein - NBP1-45296 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E.coli Species Human

Recombinant Human NMNAT-1, CF - 5865-NT-010 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Met1-Thr279, with a C-terminal 6-His tag

NMNAT1 Protein (OPPA02337) - OPPA02337 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human NMNAT1 protein - orb90195 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli Species Human

Human NaMN adenylyltransferase 1 protein - orb139400 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 10 μg, 20 μg Source Baculovirus-Insect Cells Species Human

NMNAT1 Blocking Peptide - 33R-7409 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

NMNAT1 protein (His tag) - 80R-1405 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

NMNAT1 (1-279, His-tag) - AR09580PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

NMNAT1 (1-279, His-tag) - AR09580PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

NMNAT1 - H00064802-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NMNAT1 - H00064802-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

NMNAT1 - H00064802-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NMNAT1 - H00064802-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Nicotinamide Nucleotide Adenylyltransferase 1, Human Recombinant - 228-10967-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Recombinant Human IDE - 228-10967-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human IDE - 228-10967-3 from RayBiotech Category Protein Prices $2,880.00 Sizes 3 µg Source Escherichia Coli. Species Human

NMNAT1, 1-279aa, Human, His tag, E.coli - 01-1893-1 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

NMNAT1 fusion protein - Ag1944 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

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