Gene Symbol |
MT3
|
Entrez Gene |
4504
|
Alt Symbol |
GIF, GIFB, GRIF, ZnMT3
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
metallothionein 3
|
Other Description |
MT-3|MT-III|growth inhibitory factor|metallothionein 3 (growth inhibitory factor (neurotrophic))|metallothionein-3|metallothionein-III
|
Swissprots |
Q2V574 P25713
|
Accessions |
AAA36214 AAB31396 ABB84467 EAW82866 EAW82867 EAW82868 P25713 BC013081 AAH13081 BC035624 BC047694 BI752092 BI820409 BT007030 AAP35677 CB155600 D13365 DQ891752 ABM82678 DQ894933 ABM85859 X89604 CAA61763 NM_005954 NP_005945
|
Function |
Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro.
|
Tissue Specificity |
Abundant in a subset of astrocytes in the normal human brain, but greatly reduced in the Alzheimer disease (AD) brain.
|