| Gene Symbol |
Gls
|
| Entrez Gene |
14660
|
| Alt Symbol |
6330442B14, AI314027, B230365M23Rik
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
glutaminase
|
| Other Description |
glutaminase kidney isoform, mitochondrial
|
| Swissprots |
D3Z7P3 Q69ZX9 E9PUF0
|
| Accessions |
D3Z7P3 AK031899 AK032267 AK046297 AK048072 AK049883 AK079838 AK088231 AK141044 AK173039 BAD32317 BC025534 BC050208 BC169203 BE849049 XM_006495701 XP_006495764 XM_006495702 XP_006495765 XM_006495703 XP_006495766 XM_006495704 XP_006495767 XR_373241 NM_001081081 NP_001074550 NM_001113383 NP_001106854
|
| Function |
Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. {ECO:0000269|PubMed:16641247, ECO:0000269|PubMed:22228304, ECO:0000269|PubMed:22373647}.
|
| Subcellular Location |
Isoform 1: Cytoplasm, cytosol {ECO:0000250}.
|
| Top Pathways |
Central carbon metabolism in cancer, MicroRNAs in cancer, Glutamatergic synapse, GABAergic synapse, Proximal tubule bicarbonate reclamation
|