Gene Symbol | Gls |
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Entrez Gene | 14660 |
Alt Symbol | 6330442B14, AI314027, B230365M23Rik |
Species | Mouse |
Gene Type | protein-coding |
Description | glutaminase |
Other Description | glutaminase kidney isoform, mitochondrial |
Swissprots | D3Z7P3 Q69ZX9 E9PUF0 |
Accessions | D3Z7P3 AK031899 AK032267 AK046297 AK048072 AK049883 AK079838 AK088231 AK141044 AK173039 BAD32317 BC025534 BC050208 BC169203 BE849049 XM_006495701 XP_006495764 XM_006495702 XP_006495765 XM_006495703 XP_006495766 XM_006495704 XP_006495767 XR_373241 NM_001081081 NP_001074550 NM_001113383 NP_001106854 |
Function | Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. {ECO:0000269|PubMed:16641247, ECO:0000269|PubMed:22228304, ECO:0000269|PubMed:22373647}. |
Subcellular Location | Isoform 1: Cytoplasm, cytosol {ECO:0000250}. |
Top Pathways | Central carbon metabolism in cancer, MicroRNAs in cancer, Glutamatergic synapse, GABAergic synapse, Proximal tubule bicarbonate reclamation |
Gls CRISPR/Cas9 KO Plasmid (m) - sc-420586 from Santa Cruz Biotechnology
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Gls HDR Plasmid (m) - sc-420586-HDR from Santa Cruz Biotechnology
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Gls Double Nickase Plasmid (m) - sc-420586-NIC from Santa Cruz Biotechnology
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Gls Double Nickase Plasmid (m2) - sc-420586-NIC-2 from Santa Cruz Biotechnology
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Gls CRISPR Activation Plasmid (m) - sc-420586-ACT from Santa Cruz Biotechnology
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Gls CRISPR Activation Plasmid (m2) - sc-420586-ACT-2 from Santa Cruz Biotechnology
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Gls Lentiviral Activation Particles (m) - sc-420586-LAC from Santa Cruz Biotechnology
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Gls Lentiviral Activation Particles (m2) - sc-420586-LAC-2 from Santa Cruz Biotechnology
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Gls siRNA (m) - sc-145431 from Santa Cruz Biotechnology
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Gls shRNA Plasmid (m) - sc-145431-SH from Santa Cruz Biotechnology
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Gls shRNA (m) Lentiviral Particles - sc-145431-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN31958 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND31958 from Sigma-Aldrich
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GLS siRNA (Mouse) - CRM1589 from Cohesion Biosciences
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GLS - MBS8235416 from MyBioSource
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shRNA set against Mouse GLS (NM_001081081.2) - SHH302042 from Creative biogene
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shRNA set against Mouse Gls(NM_001081081.2) - SHH087941 from Creative biogene
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shRNA set against Mouse Gls(NM_001113383.1) - SHH087977 from Creative biogene
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Mouse GLS siRNA - orb281065 from Biorbyt
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GLS shRNA Plasmid (Mouse) - CHM1589 from Cohesion Biosciences
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GLS miRNA 3'UTR clone - MiUTR1M-05090 from Creative biogene
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GLS miRNA 3'UTR clone - MiUTR1M-05091 from Creative biogene
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