Gene Symbol | DNAJC6 |
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Entrez Gene | 9829 |
Alt Symbol | DJC6, PARK19 |
Species | Human |
Gene Type | protein-coding |
Description | DnaJ (Hsp40) homolog, subfamily C, member 6 |
Other Description | DnaJ (Hsp40) homolog, subfamily B, member 6|auxilin|putative tyrosine-protein phosphatase auxilin |
Swissprots | Q5T614 Q32M66 O75061 D3DQ65 B7Z3V8 D3DQ66 Q5T615 Q4G0K1 |
Accessions | CCE46052 EAX06533 EAX06534 EAX06535 EAX06536 EAX06537 O75061 AB007942 BAA32318 AK296408 BAH12344 BC051722 AAH51722 BC109279 AAI09280 BC109280 AAI09281 BP311649 BQ423527 BX647203 CR747692 DC332732 DR002818 XM_011542483 XP_011540785 XM_011542484 XP_011540786 XM_011542485 XP_011540787 XM_011542486 XP_011540788 XM_011542487 XP_011540789 XM_011542488 XP_011540790 XM_011542489 XP_011540791 NM_001256864 NP_001243793 NM_001256865 NP_001243794 NM_014787 NP_055602 |
Function | Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity). {ECO:0000250}. |
Tissue Specificity | Expressed in various brain regions, including cerebellum, corpus callosum, cortex, striatum, brainstem, pons, putamen, spinal cord and substantia nigra. Very low expression in non-neural tissues such as leukocytes, liver, adipose tissue, skeletal muscle and bone marrow. {ECO:0000269|PubMed:23211418}. |
Top Pathways | Endocytosis |
DnaJC6 CRISPR/Cas9 KO Plasmid (h) - sc-418243 from Santa Cruz Biotechnology
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DnaJC6 HDR Plasmid (h) - sc-418243-HDR from Santa Cruz Biotechnology
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DnaJC6 Double Nickase Plasmid (h) - sc-418243-NIC from Santa Cruz Biotechnology
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DnaJC6 Double Nickase Plasmid (h2) - sc-418243-NIC-2 from Santa Cruz Biotechnology
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DnaJC6 CRISPR Activation Plasmid (h) - sc-418243-ACT from Santa Cruz Biotechnology
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DnaJC6 CRISPR Activation Plasmid (h2) - sc-418243-ACT-2 from Santa Cruz Biotechnology
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DnaJC6 Lentiviral Activation Particles (h) - sc-418243-LAC from Santa Cruz Biotechnology
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DnaJC6 Lentiviral Activation Particles (h2) - sc-418243-LAC-2 from Santa Cruz Biotechnology
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DnaJC6 siRNA (h) - sc-88612 from Santa Cruz Biotechnology
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DnaJC6 shRNA Plasmid (h) - sc-88612-SH from Santa Cruz Biotechnology
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DnaJC6 shRNA (h) Lentiviral Particles - sc-88612-V from Santa Cruz Biotechnology
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DNAJC6 RNAi - H00009829-R01 from Novus Biologicals
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MISSION® esiRNA - EHU055231 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7382 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7382 from Sigma-Aldrich
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DNAJC6 siRNA (Human) - CRH6584 from Cohesion Biosciences
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DNAJC6 - MBS8228596 from MyBioSource
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shRNA set against Human DNAJC6 (NM_014787.3) - SHH279701 from Creative biogene
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Human DNAJC6 siRNA - orb267086 from Biorbyt
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DNAJC6 shRNA Plasmid (Human) - CHH6584 from Cohesion Biosciences
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