| Gene Symbol |
AGR2
|
| Entrez Gene |
10551
|
| Alt Symbol |
AG2, GOB-4, HAG-2, HEL-S-116, PDIA17, XAG-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
anterior gradient 2
|
| Other Description |
AG-2|HPC8|anterior gradient homolog 2|anterior gradient protein 2 homolog|epididymis secretory protein Li 116|protein disulfide isomerase family A, member 17|secreted cement gland homolog|secreted cement gland protein XAG-2 homolog
|
| Swissprots |
O95994
|
| Accessions |
AAP22354 AAY84773 AAY84774 AAY84775 AAY84776 CAC69703 CAM55980 EAL24283 EAW93682 EAW93683 O95994 AF007791 AAC77358 AF038451 AAC82614 AF038452 AF087879 AAP97179 AF088867 AAF22484 AF115926 AAL54870 AK223067 BAD96787 AK296721 BAG59310 AK312942 BAG35784 AY359009 AAQ89368 BC015503 AAH15503 BF680655 BT007048 AAP35697 DQ890645 ABM81571 DQ893825 ABM84751 FJ224307 ACI45999 KJ767789 AJO53280 KJ767791 KJ767792 KJ767793 XM_005249581 XP_005249638 NM_006408 NP_006399
|
| Function |
Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. {ECO:0000250, ECO:0000269|PubMed:18199544}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:15834940}. Endoplasmic reticulum {ECO:0000250}.
|
| Tissue Specificity |
Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines. {ECO:0000269|PubMed:9790916}.
|