| Gene Symbol | HLA-DOB |
|---|---|
| Entrez Gene | 3112 |
| Alt Symbol | DOB |
| Species | Human |
| Gene Type | protein-coding |
| Description | major histocompatibility complex, class II, DO beta |
| Other Description | HLA class II histocompatibility antigen, DO beta chain|MHC class II antigen DOB |
| Swissprots | Q29746 Q6FHC2 Q29825 B0V0Y0 P13765 |
| Accessions | AAA59717 AHW47923 AHW47940 AHW47957 AHW47974 CAA47028 CAA60789 EAX03638 EAX03639 EAX03640 EAX03641 P13765 AK301415 BAH13478 AK316197 BAH14568 AY645723 AAV97948 BC006097 AAH06097 BC020226 BM152694 BQ010608 CR541811 CAG46610 CR541832 CAG46631 M26040 AAA59718 X03066 CAA26870 NM_002120 NP_002111 |
| Function | Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM. |
| Subcellular Location | Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER. |
| Top Pathways | Leishmaniasis, HTLV-I infection, Influenza A, Tuberculosis, Herpes simplex infection |