Gene Symbol | RHO |
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Entrez Gene | 6010 |
Alt Symbol | CSNBAD1, OPN2, RP4 |
Species | Human |
Gene Type | protein-coding |
Description | rhodopsin |
Other Description | opsin 2, rod pigment|opsin-2 |
Swissprots | Q2M249 Q16414 P08100 |
Accessions | AAA97436 AAB35906 AAC31763 AAD14357 AIK20539 BAC05894 EAW79244 P08100 AM392780 CAL37658 BC111451 AAI11452 BC112104 AAI12105 BC112106 AAI12107 BX537381 CAD97623 NM_000539 NP_000530 |
Function | Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal. |
Subcellular Location | Membrane {ECO:0000269|PubMed:19934218}; Multi-pass membrane protein {ECO:0000269|PubMed:19934218}. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to the rod outer segment (OS) photosensory cilia. |
Tissue Specificity | Rod shaped photoreceptor cells which mediates vision in dim light. |
Top Pathways | Phototransduction |
rhodopsin CRISPR/Cas9 KO Plasmid (h) - sc-401026 from Santa Cruz Biotechnology
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rhodopsin HDR Plasmid (h) - sc-401026-HDR from Santa Cruz Biotechnology
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rhodopsin Double Nickase Plasmid (h) - sc-401026-NIC from Santa Cruz Biotechnology
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rhodopsin Double Nickase Plasmid (h2) - sc-401026-NIC-2 from Santa Cruz Biotechnology
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rhodopsin CRISPR Activation Plasmid (h) - sc-401026-ACT from Santa Cruz Biotechnology
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rhodopsin CRISPR Activation Plasmid (h2) - sc-401026-ACT-2 from Santa Cruz Biotechnology
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rhodopsin Lentiviral Activation Particles (h) - sc-401026-LAC from Santa Cruz Biotechnology
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rhodopsin Lentiviral Activation Particles (h2) - sc-401026-LAC-2 from Santa Cruz Biotechnology
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rhodopsin siRNA (h) - sc-40150 from Santa Cruz Biotechnology
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rhodopsin shRNA Plasmid (h) - sc-40150-SH from Santa Cruz Biotechnology
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rhodopsin shRNA (h) Lentiviral Particles - sc-40150-V from Santa Cruz Biotechnology
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Rhodopsin RNAi - H00006010-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN1738 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1738 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10207 from Sigma-Aldrich
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RHO siRNA (Human) - CRH4077 from Cohesion Biosciences
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RHO - MBS828797 from MyBioSource
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shRNA set against Human RHO (NM_000539.3) - SHH395252 from Creative biogene
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Human RHO siRNA - orb264579 from Biorbyt
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RHO shRNA Plasmid (Human) - CHH4077 from Cohesion Biosciences
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RHO miRNA 3'UTR clone - MiUTR4H-TG07503 from Creative biogene
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