ELF4

Gene Symbol	ELF4
Entrez Gene	2000
Alt Symbol	ELFR, MEF
Species	Human
Gene Type	protein-coding
Description	E74-like factor 4 (ets domain transcription factor)
Other Description	ETS-related transcription factor Elf-4|myeloid Elf-1-like factor
Swissprots	Q99607 O60435 D3DTG1
Accessions	EAX11813 EAX11814 Q99607 AF000670 AAC17452 AK314972 BC017194 AAH17194 BC114355 BC114356 CD364651 CN314421 DN999740 DQ892234 ABM83160 DQ895435 ABM86361 U32645 AAB53693 XM_005262389 XP_005262446 XM_011531307 XP_011529609 XM_011531308 XP_011529610 NM_001127197 NP_001120669 NM_001421 NP_001412
Function	Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. {ECO:0000250, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:14625302, ECO:0000269|PubMed:14976184, ECO:0000269|PubMed:19380490, ECO:0000269|PubMed:8895518, ECO:0000269|PubMed:9524226}.
Subcellular Location	Nucleus, PML body {ECO:0000269|PubMed:14976184}. Note=Accumulation into PML nuclear bodies is mediated by PML.
Tissue Specificity	Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels of expression in Jurkat T-cells and other T-cell lines and no expression in brain. {ECO:0000269|PubMed:8895518, ECO:0000269|PubMed:9524226}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Elf4/MEF peptide - ab28459 from Abcam Category Peptide

Human Elf4/MEF protein fragment - ab158352 from Abcam Category Protein Source Wheat germ Species Human

ELF4 / MEF Antibody Blocking Peptide - LS-E1921 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ELF4 / MEF Antibody Blocking Peptide - LS-E8746 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ELF4 / MEF Antibody Blocking Peptide - LS-E11269 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ELF4 / MEF Antibody Blocking Peptide - LS-E11057 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ELF4 / MEF Antibody Blocking Peptide - LS-E13359 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Elf4/MEF Protein - H00002000-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ELF4-Antibody-N-term-Blocking-peptide - BP12761a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ELF4-Antibody-Center-Blocking-Peptide - BP7185c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ELF4 Blocking Peptide - abx062576 from Abbexa Category Peptide Species Human, Mouse, Rat, Pig

ELF4 - H00002000-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ELF4 - H00002000-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ELF4 fusion protein - Ag8836 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human ELF4, His-tagged - ELF4-12401H from Creative Biomart Category Protein Source E.coli Species Human

ELF4 Blocking Peptide - CBP1382 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Pig

Elf-4 Peptide - BS5710P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human ETS-related transcription factor Elf-4(ELF4) - CSB-YP857453HU CSB-EP857453HU CSB-BP857453HU CSB-MP857453HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Elf4/MEF Recombinant Protein Antigen - NBP2-33286PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ELF4 Peptide, Human - M34GP04856H from Creative Peptides Category Peptide Source Synthetic. Species Human

ELF4 peptide - orb217245 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

ELF4 fusion protein - Ag26617 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

ETS-related transcription factor Elf-4 (ELF4), Recombinant Protein - MBS1421191 from MyBioSource Category Protein Prices $1,465.00, $1,465.00, $1,695.00, $1,695.00, $2,490.00, $2,490.00, $2,935.00, $2,935.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Elf4/MEF Recombinant Protein Antigen - NBP2-56927PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ELF4 fusion protein - Ag26589 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

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