| Gene Symbol |
SLC22A7
|
| Entrez Gene |
10864
|
| Alt Symbol |
NLT, OAT2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 22 (organic anion transporter), member 7
|
| Other Description |
hOAT2|liver-specific transporter|novel liver transporter|organic anion transporter 2|solute carrier family 22 member 7
|
| Swissprots |
Q9H2W5 Q5T050 Q5T048 Q5T046 B2CZX6 Q9Y694
|
| Accessions |
ACB21045 EAX04171 EAX04172 EAX04173 EAX04174 EAX04175 EAX04176 Q9Y694 AA705161 AF097518 AAD37091 AF210455 AAG43523 AI928177 AK290796 BAF83485 AK290806 BAF83495 AK309570 AK314822 BAG37344 AY050498 AAL12496 BC017963 AAH17963 BC033805 AAH33805 DA640137 DQ893614 ABM84540 DQ896844 ABM87843 XM_006714970 XP_006715033 XM_006714971 XP_006715034 XM_011514256 XP_011512558 XM_011514257 XP_011512559 XM_011514258 XP_011512560 XM_011514259 XP_011512561 XM_011514260 XP_011512562 XM_011514261 XP_011512563 XM_011514262 XP_011512564 XM_011514263 XP_011512565 NM_006672 NP_006663 NM_153320 NP_696961
|
| Function |
Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate. {ECO:0000269|PubMed:11327718, ECO:0000269|PubMed:11855680, ECO:0000269|PubMed:11907186, ECO:0000269|PubMed:12023506, ECO:0000269|PubMed:15901346}.
|
| Subcellular Location |
Basolateral cell membrane {ECO:0000269|PubMed:11907186, ECO:0000269|PubMed:12023506}; Multi- pass membrane protein {ECO:0000269|PubMed:11907186, ECO:0000269|PubMed:12023506}. Note=Apical side of the renal tubule.
|
| Tissue Specificity |
Expressed in liver and kidney. {ECO:0000269|PubMed:11327718, ECO:0000269|PubMed:11907186, ECO:0000269|PubMed:15901346}.
|
| Top Pathways |
Bile secretion
|