Gene Symbol | SLC22A7 |
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Entrez Gene | 10864 |
Alt Symbol | NLT, OAT2 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 22 (organic anion transporter), member 7 |
Other Description | hOAT2|liver-specific transporter|novel liver transporter|organic anion transporter 2|solute carrier family 22 member 7 |
Swissprots | Q9H2W5 Q5T050 Q5T048 Q5T046 B2CZX6 Q9Y694 |
Accessions | ACB21045 EAX04171 EAX04172 EAX04173 EAX04174 EAX04175 EAX04176 Q9Y694 AA705161 AF097518 AAD37091 AF210455 AAG43523 AI928177 AK290796 BAF83485 AK290806 BAF83495 AK309570 AK314822 BAG37344 AY050498 AAL12496 BC017963 AAH17963 BC033805 AAH33805 DA640137 DQ893614 ABM84540 DQ896844 ABM87843 XM_006714970 XP_006715033 XM_006714971 XP_006715034 XM_011514256 XP_011512558 XM_011514257 XP_011512559 XM_011514258 XP_011512560 XM_011514259 XP_011512561 XM_011514260 XP_011512562 XM_011514261 XP_011512563 XM_011514262 XP_011512564 XM_011514263 XP_011512565 NM_006672 NP_006663 NM_153320 NP_696961 |
Function | Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate. {ECO:0000269|PubMed:11327718, ECO:0000269|PubMed:11855680, ECO:0000269|PubMed:11907186, ECO:0000269|PubMed:12023506, ECO:0000269|PubMed:15901346}. |
Subcellular Location | Basolateral cell membrane {ECO:0000269|PubMed:11907186, ECO:0000269|PubMed:12023506}; Multi- pass membrane protein {ECO:0000269|PubMed:11907186, ECO:0000269|PubMed:12023506}. Note=Apical side of the renal tubule. |
Tissue Specificity | Expressed in liver and kidney. {ECO:0000269|PubMed:11327718, ECO:0000269|PubMed:11907186, ECO:0000269|PubMed:15901346}. |
Top Pathways | Bile secretion |
OAT2 (C-12) - sc-132388 from Santa Cruz Biotechnology
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OAT2 (P-13) - sc-132389 from Santa Cruz Biotechnology
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OAT2 (G-18) - sc-102044 from Santa Cruz Biotechnology
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Anti-SLC22A7 antibody - ab58683 from Abcam
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Anti-SLC22A7 antibody - C-terminal - ab191018 from Abcam
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Anti-SLC22A7 antibody - N-terminal - ab186476 from Abcam
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Anti-SLC22A7 / OAT2 Antibody (N-Terminus) - LS-C17008 from LifeSpan Bioscience
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Anti-SLC22A7 / OAT2 Antibody (N-Terminus) - LS-C17009 from LifeSpan Bioscience
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Anti-SLC22A7 / OAT2 Antibody (aa1-50) - LS-C205726 from LifeSpan Bioscience
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Anti-SLC22A7 / OAT2 Antibody (aa514-530) - LS-C313517 from LifeSpan Bioscience
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Anti-SLC22A7 / OAT2 Antibody (aa51-100) - LS-C31903 from LifeSpan Bioscience
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Anti-SLC22A7 / OAT2 Antibody (C-Terminus) - LS-C40397 from LifeSpan Bioscience
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Anti-SLC22A7 / OAT2 Antibody (aa72-121) - LS-C80491 from LifeSpan Bioscience
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SLC22A7 Antibody - NBP1-62660 from Novus Biologicals
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SLC22A7 Antibody - NBP1-69691 from Novus Biologicals
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SLC22A7 Antibody - NBP1-82552 from Novus Biologicals
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SLC22A7 Antibody - NBP1-69696 from Novus Biologicals
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Anti-SLC22A7 antibody produced in rabbit - HPA030220 from Sigma-Aldrich
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Anti-SLC22A7 (AB1) antibody produced in rabbit - AV42708 from Sigma-Aldrich
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SLC22A7 antibody - N-terminal region (ARP42306_T100) - ARP42306_T100 from Aviva Systems Biology
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SLC22A7 antibody - N-terminal region (ARP42307_P050) - ARP42307_P050 from Aviva Systems Biology
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SLC22A7 Antibody - N-terminal region (ARP42707_P050) - ARP42707_P050 from Aviva Systems Biology
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SLC22A7 antibody - C-terminal region (ARP42708_P050) - ARP42708_P050 from Aviva Systems Biology
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SLC22A7 antibody - 70R-7526 from Fitzgerald
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SLC22A7 antibody - 70R-1912 from Fitzgerald
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