| Gene Symbol |
EP400
|
| Entrez Gene |
57634
|
| Alt Symbol |
CAGH32, P400, TNRC12
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
E1A binding protein p400
|
| Other Description |
CAG repeat protein 32|E1A-binding protein p400|domino homolog|hDomino|p400 SWI2/SNF2-related protein|p400 kDa SWI2/SNF2-related protein|trinucleotide repeat containing 12|trinucleotide repeat-containing gene 12 protein
|
| Swissprots |
Q8NE05 O15411 Q96L91 Q96JK7 Q9P230 Q8N8Q7 Q6P2F5
|
| Accessions |
EAW98534 EAW98535 EAW98536 Q96L91 AB040931 BAA96022 AB058721 BAB47447 AK025040 AK074395 AK096311 BAC04759 AK097299 AK124012 AK127058 AL832718 AW376113 AY044869 AAK97789 BC016068 BC037208 AAH37208 BC064554 AAH64554 BC150291 AAI50292 BX369075 DA450209 JF432826 ADZ16043 U80743 AAB91441 NM_015409 NP_056224
|
| Function |
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00549}.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:11509179}.
|
