TSEN34

Gene Symbol TSEN34
Entrez Gene 79042
Alt Symbol LENG5, PCH2C, SEN34, SEN34L
Species Human
Gene Type protein-coding
Description TSEN34 tRNA splicing endonuclease subunit
Other Description CTD-3093M3.1|hsSen34|leukocyte receptor cluster (LRC) member 5|leukocyte receptor cluster member 5|tRNA-intron endonuclease Sen34|tRNA-splicing endonuclease subunit Sen34
Swissprots Q9BVT1 A6NNB1 Q9H6H5 Q9BSV6 B0V3J1
Accessions EAW72203 EAW72204 EAW72205 EAW72206 EAW72207 Q9BSV6 AF211970 AK025929 BAB15284 AK054944 AK225385 AK226013 AK300054 BAG61863 BC000944 BC004530 AAH04530 BC020805 AAH20805 BE779123 BM977824 CA437038 CN256589 DB463309 DQ893336 ABM84262 DQ896652 ABM87651 DR763016 XM_005259241 XP_005259298 XM_005277087 XP_005277144 XM_005277276 XP_005277333 XM_005278290 XP_005278347 XM_006726203 XP_006726266 XM_011527294 XP_011525596 XM_011527295 XP_011525597 XM_011547122 XP_011545424 XM_011547123 XP_011545425 XM_011547532 XP_011545834 XM_011547533 XP_011545835 XM_011547792 XP_011546094 XM_011547793 XP_011546095 XM_011547794 XP_011546096 XM_011547989 XP_011546291 XM_011547990 XP_011546292 XM_011547991 XP_011546293 XM_011548168 XP_011546470 XM_011548169 XP_011546471 XM_011548170 XP_011546472 XM_011548360 XP_011546662 XM_011548361 XP_011546663 XM_011548362 XP_011546664 XM_011548568 XP_011546870 XM_011548569 XP_011546871 XM_011548625 XP_011546927 XM_011548626 XP_011546928 XM_011548627 XP_011546929 XM_011548715 XP_011547017 XM_011548716 XP_011547018 NM_001077446 NP_001070914 NM_001282332 NP_001269261 NM_001282333 NP_001269262 NM_024075 NP_076980
Function Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'- end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}.
Subcellular Location Nucleus {ECO:0000269|PubMed:15109492}. Nucleus, nucleolus {ECO:0000269|PubMed:15109492}. Note=May be transiently localized in the nucleolus.

Anti-TSEN34 antibody - ab68868 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-TSEN34 antibody (ab68868) at 1/500 dilutionLane 1 : TSEN34 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

TSEN34 Antibody - H00079042-B01 from Novus Biologicals

Prices $359.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: TSEN34 Antibody [H00079042-B01] - Analysis of TSEN34 expression in HeLa.

TSEN34 Antibody - NBP1-81315 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: TSEN34 Antibody [NBP1-81315] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

TSEN34 Antibody - H00079042-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: TSEN34 Antibody [H00079042-A01] - TSEN34 polyclonal antibody (A01), Lot # 060608JCS1 Western Blot analysis of TSEN34 expression in MES-SA/Dx5 ( Cat # L021V1 ).

TSEN34 Antibody - H00079042-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: TSEN34 Antibody [H00079042-B01P] - Analysis of TSEN34 expression in Hela S3 NE.

Anti-TSEN34 antibody produced in rabbit - HPA041111 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TSEN34: <B>Cat. No. HPA041111</B>: Immunohistochemical staining of human thyroid gland shows strong nuclear positivity in glandular cells.

Anti-TSEN34 antibody produced in mouse - SAB1400692 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Polyclonal Anti-TSEN34, antibody produced in mouse, purified immunoglobulin: <B>Cat. No. SAB1400692</B>: Antibody concentration: 1.0 μg/mL using HeLa cells.

SEN34 Antibody - C-terminal region (ARP75754_P050) - ARP75754_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TSEN34 / SEN34 antibody - H00079042-B01 from Acris Antibodies

Prices $360.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
TSEN34 MaxPab polyclonal antibody. Western Blot analysis of TSEN34 expression in HeLa.

TSEN34 / SEN34 antibody - H00079042-B01P from Acris Antibodies

Prices $360.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Immunofluorescence of purified MaxPab antibody to TSEN34 on HeLa cell. [antibody concentration 10 ug/ml]

TSEN34 / SEN34 antibody - H00079042-A01 from Acris Antibodies

Prices $300.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
TSEN34 polyclonal antibody (A01), Lot # 060608JCS1 Western Blot analysis of TSEN34 expression in MES-SA/Dx5 ( Cat # L021V1 ).

Anti-TSEN34 monoclonal antibody - DCABH-13855 from Creative Diagnostics

Host Rabbit
Clonality Monoclonal

Anti-TSEN34 (aa 1-99) polyclonal antibody - DPAB-DC3256 from Creative Diagnostics

Host Mouse
Clonality Polyclonal

TSEN34, Polyclonal Antibody - MBS6008212 from MyBioSource

Prices $580.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

SEN34 antibody - orb327595 from Biorbyt

Prices $502.00
Sizes 100 μl
Host Rabbit
Clonality Polyclonal

Anti-TSEN34 Antibody A12386 - A12386 from Boster Bio

Prices $299.00
Sizes 1
Host Rabbit
Clonality Polyclonal

SEN34 Antibody - C-terminal region : Biotin (ARP75754_P050-Biotin) - ARP75754_P050-Biotin from Aviva Systems Biology

Host Rabbit
Clonality Polyclonal

SEN34 Antibody - C-terminal region : FITC (ARP75754_P050-FITC) - ARP75754_P050-FITC from Aviva Systems Biology

Host Rabbit
Clonality Polyclonal

SEN34 Antibody - C-terminal region : HRP (ARP75754_P050-HRP) - ARP75754_P050-HRP from Aviva Systems Biology

Host Rabbit
Clonality Polyclonal

TSEN34 Antibody - middle region (ARP77663_P050) - ARP77663_P050 from Aviva Systems Biology

Host Rabbit
Clonality Polyclonal

TSEN34 antibody - center region (OAAB06183) - OAAB06183 from Aviva Systems Biology

Host Rabbit
Clonality Polyclonal
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