| Gene Symbol |
TSEN34
|
| Entrez Gene |
79042
|
| Alt Symbol |
LENG5, PCH2C, SEN34, SEN34L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TSEN34 tRNA splicing endonuclease subunit
|
| Other Description |
CTD-3093M3.1|hsSen34|leukocyte receptor cluster (LRC) member 5|leukocyte receptor cluster member 5|tRNA-intron endonuclease Sen34|tRNA-splicing endonuclease subunit Sen34
|
| Swissprots |
Q9BVT1 A6NNB1 Q9H6H5 Q9BSV6 B0V3J1
|
| Accessions |
EAW72203 EAW72204 EAW72205 EAW72206 EAW72207 Q9BSV6 AF211970 AK025929 BAB15284 AK054944 AK225385 AK226013 AK300054 BAG61863 BC000944 BC004530 AAH04530 BC020805 AAH20805 BE779123 BM977824 CA437038 CN256589 DB463309 DQ893336 ABM84262 DQ896652 ABM87651 DR763016 XM_005259241 XP_005259298 XM_005277087 XP_005277144 XM_005277276 XP_005277333 XM_005278290 XP_005278347 XM_006726203 XP_006726266 XM_011527294 XP_011525596 XM_011527295 XP_011525597 XM_011547122 XP_011545424 XM_011547123 XP_011545425 XM_011547532 XP_011545834 XM_011547533 XP_011545835 XM_011547792 XP_011546094 XM_011547793 XP_011546095 XM_011547794 XP_011546096 XM_011547989 XP_011546291 XM_011547990 XP_011546292 XM_011547991 XP_011546293 XM_011548168 XP_011546470 XM_011548169 XP_011546471 XM_011548170 XP_011546472 XM_011548360 XP_011546662 XM_011548361 XP_011546663 XM_011548362 XP_011546664 XM_011548568 XP_011546870 XM_011548569 XP_011546871 XM_011548625 XP_011546927 XM_011548626 XP_011546928 XM_011548627 XP_011546929 XM_011548715 XP_011547017 XM_011548716 XP_011547018 NM_001077446 NP_001070914 NM_001282332 NP_001269261 NM_001282333 NP_001269262 NM_024075 NP_076980
|
| Function |
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'- end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15109492}. Nucleus, nucleolus {ECO:0000269|PubMed:15109492}. Note=May be transiently localized in the nucleolus.
|
