| Gene Symbol |
Egfr
|
| Entrez Gene |
13649
|
| Alt Symbol |
9030024J15Rik, AI552599, Erbb, Errb1, Errp, Wa5, wa-2, wa2
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
epidermal growth factor receptor
|
| Other Description |
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog|waved 2
|
| Swissprots |
Q01279
|
| Accessions |
AAG28045 AAG28046 AAG28047 AAG43241 AAL56615 EDL40666 EDL40667 Q01279 AF124513 AAD44149 AF275367 AAG24386 AF277898 AAK01081 AK004883 BAB23641 AK004911 BAB23662 AK004944 BAB23688 AK014017 AK033431 AK049452 AK087861 AK134262 AK163338 BAE37306 BC023729 AAH23729 BC030681 BQ553815 BY725722 L06864 AAA53029 U03425 AAA17899 X59698 CAA42219 X78987 CAA55587 Z12608 CAA78249 NM_007912 NP_031938 NM_207655 NP_997538
|
| Function |
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-ca
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Endosome. Endosome membrane. Nucleus {ECO:0000250}. Note=In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER. Endocytosed upon activation by ligand. Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (By similarity). {ECO:0000250}.
|
| Top Pathways |
Estrogen signaling pathway, PI3K-Akt signaling pathway, GnRH signaling pathway, Bladder cancer, Melanoma
|