Egfr

Gene Symbol	Egfr
Entrez Gene	13649
Alt Symbol	9030024J15Rik, AI552599, Erbb, Errb1, Errp, Wa5, wa-2, wa2
Species	Mouse
Gene Type	protein-coding
Description	epidermal growth factor receptor
Other Description	avian erythroblastic leukemia viral (v-erb-b) oncogene homolog|waved 2
Swissprots	Q01279
Accessions	AAG28045 AAG28046 AAG28047 AAG43241 AAL56615 EDL40666 EDL40667 Q01279 AF124513 AAD44149 AF275367 AAG24386 AF277898 AAK01081 AK004883 BAB23641 AK004911 BAB23662 AK004944 BAB23688 AK014017 AK033431 AK049452 AK087861 AK134262 AK163338 BAE37306 BC023729 AAH23729 BC030681 BQ553815 BY725722 L06864 AAA53029 U03425 AAA17899 X59698 CAA42219 X78987 CAA55587 Z12608 CAA78249 NM_007912 NP_031938 NM_207655 NP_997538
Function	Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-ca
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Endosome. Endosome membrane. Nucleus {ECO:0000250}. Note=In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER. Endocytosed upon activation by ligand. Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (By similarity). {ECO:0000250}.
Top Pathways	Estrogen signaling pathway, PI3K-Akt signaling pathway, GnRH signaling pathway, Bladder cancer, Melanoma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse EGFR protein - orb138744 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Mouse

Mouse EGFR protein (His Tag) - orb138745 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Mouse

EGFR Recombinant Protein - 96-263 from ProSci Category Protein Prices $500.00 Sizes 50 µg Source HEK293 cells Species Mouse

EGFR, Active Mouse Recombinant Protein - GWB-PSFD4D from Genway Biotech Category Protein Prices $410.00 Sizes 10 µg Species Mouse

Recombinant Mouse Egfr, His-tagged - Egfr-5224M from Creative Biomart Category Protein Source HEK293 Cells Species Mouse

Recombinant Mouse EGFR, His tagged - EGFR-101M from Creative Biomart Category Protein Source Human Cells Species Mouse

Recombinant Mouse EGFR, Fc tagged - EGFR-102M from Creative Biomart Category Protein Source Human Cells Species Mouse

Mouse EGFR / HER1 / ErbB1 Protein (Fc Tag) - 51091-M02H-50 from Sino Biological Category Protein Source Human Cells Species Mouse

Mouse EGFR / HER1 / ErbB1 Protein (His Tag) - 51091-M08H-100 from Sino Biological Category Protein Source Human Cells Species Mouse

Mouse EGF R Protein - EGR-M5224 from ACROBiosystems Category Protein Prices $350.00, $1,980.00 Sizes 50 µg, 1 mg (500ug x 2) Source Mouse EGF R, His Tag (EGR-M5224) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Ser 647 (Accession # Q01279.1). Species Mouse

Human CellExp™ ErbB1/EGFR, mouse recombinant - 7402-10 from Biovision Category Protein Prices $225.00 Sizes 10 μg Source HEK293 cells Species Human

Epidermal Growth Factor Receptor Protein (Recombinant) - abx167242 from Abbexa Category Protein Source Mouse Species Mouse

Recombinant Mouse EGFR / HER1 / ErbB1 Protein (His tag) - PKSM040365 from Elabscience Category Protein Source Human Cell Species Mouse

Recombinant Mouse EGFR / HER1 / ErbB1 Protein (Fc tag) - PKSM040366 from Elabscience Category Protein Source Human Cell Species Mouse

Mouse EGF R protein - orb257420 from Biorbyt Category Protein Prices $578.00, $2,967.00 Sizes 50 μg, 1 mg Species Mouse

Mouse-Egfr-Blocking-Peptide-P1116 - BP20926a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg Species Mouse

Human CellExp™ ErbB1/EGFR, mouse recombinant - 7402 from Biovision Category Protein Prices $230.00 Sizes 10 μg Source HEK293 cells Species Human

Recombinant Epidermal Growth Factor Receptor (EGFR) - RPU52018 from Biomatik Category Protein Prices $185.00, $378.00, $578.00, $688.80 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Mouse

EGFR Recombinant Protein (OPCD02869) - OPCD02869 from Aviva Systems Biology Category Protein Source E.coli Species Mouse

Mouse EGFR / HER1 / ErbB1 Protein (Fc Tag) - 51091-M02H from ABclonal Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Mouse

Mouse EGFR / HER1 / ErbB1 Protein (His Tag) - 51091-M08H from ABclonal Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Mouse

Recombinant Anti-Mouse Egfr VHH Single Domain Antibody - NABG-056 from Creative Biolabs Species Mouse

Recombinant Mouse Anti-Mouse EGFR Antibody Fab Fragment (7A7) - PFBW-088 from Creative Biolabs Species Mouse

Recombinant Mouse Anti-Mouse EGFR Antibody (7A7) - PABW-088 from Creative Biolabs Species Mouse

Recombinant Mouse Anti-Mouse EGFR Antibody scFv Fragment (7A7) - PSBW-088 from Creative Biolabs Species Mouse

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