Gene Symbol | MAEA |
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Entrez Gene | 10296 |
Alt Symbol | EMLP, EMP, GID9, HLC-10, PIG5 |
Species | Human |
Gene Type | protein-coding |
Description | macrophage erythroblast attacher |
Other Description | GID complex subunit 9, FYV10 homolog|cell proliferation-inducing gene 5 protein|erythroblast macrophage protein|human lung cancer oncogene 10 protein|lung cancer-related protein 10 |
Swissprots | Q9BQ11 Q9NW84 Q5JB54 Q9H9V6 Q9H9Z4 Q7L5Y9 O95285 Q6ZRD6 |
Accessions | EAW82586 EAW82587 EAW82588 EAW82589 EAW82590 EAW82591 EAW82592 EAW82593 EAW82594 EAW82595 EAW82596 Q7L5Y9 AB208907 BAD92144 AF084928 AAC67543 AK001088 BAA91499 AK022515 BAB14072 AK022586 BAB14113 AK091951 BAG52449 AK094253 AK125501 AK127875 BAG54590 AK128302 AK296174 BAG58910 AK298944 BAG61043 AK300572 BAG62274 AK301155 BAG62745 AK308901 AY189687 AAO85220 AY236486 AAP74806 BC001225 AAH01225 BC006470 AAH06470 BT006957 AAP35603 BU607457 DC299400 DC331820 DC400017 XM_005272247 XP_005272304 XM_006713849 XP_006713912 XM_006713850 XP_006713913 XM_011513376 XP_011511678 XM_011513377 XP_011511679 XM_011513378 XP_011511680 XM_011513379 XP_011511681 XM_011513380 XP_011511682 XR_924910 NM_001017405 NP_001017405 NM_001297430 NP_001284359 NM_001297431 NP_001284360 NM_001297432 NP_001284361 NM_001297433 NP_001284362 NM_005882 NP_005873 NR_123716 |
Function | Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events. {ECO:0000269|PubMed:16510120, ECO:0000269|PubMed:9763581}. |
Subcellular Location | Nucleus matrix {ECO:0000269|PubMed:16510120}. Cell membrane {ECO:0000269|PubMed:16510120}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16510120}. Note=Localized as nuclear speckled- like pattern. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:16510120, ECO:0000269|PubMed:9763581}. |
Emp (I-12) - sc-167747 from Santa Cruz Biotechnology
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Anti-MAEA antibody - ab65239 from Abcam
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Anti-MAEA / EMP Antibody (Glu207) - LS-C191986 from LifeSpan Bioscience
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Anti-MAEA / EMP Antibody (aa32-81) - LS-C151732 from LifeSpan Bioscience
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Anti-MAEA / EMP Antibody (aa16-42, AP) - LS-C237346 from LifeSpan Bioscience
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Anti-MAEA / EMP Antibody (aa16-42, APC) - LS-C237347 from LifeSpan Bioscience
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Anti-MAEA / EMP Antibody (aa16-42, FITC) - LS-C237349 from LifeSpan Bioscience
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Anti-MAEA / EMP Antibody (aa16-42, Biotin) - LS-C237350 from LifeSpan Bioscience
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Anti-MAEA / EMP Antibody (aa16-42, PE) - LS-C237351 from LifeSpan Bioscience
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Anti-MAEA / EMP Antibody (aa16-42, Azide-free, HRP) - LS-C248754 from LifeSpan Bioscience
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Anti-MAEA / EMP Antibody (aa181-230) - LS-C119116 from LifeSpan Bioscience
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Anti-MAEA / EMP Antibody (aa16-42) - LS-C158091 from LifeSpan Bioscience
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Anti-MAEA / EMP Antibody (aa136-379, Biotin) - LS-C299498 from LifeSpan Bioscience
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Anti-MAEA / EMP Antibody (aa136-379, FITC) - LS-C303586 from LifeSpan Bioscience
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Anti-MAEA / EMP Antibody (aa15-42) - LS-C322791 from LifeSpan Bioscience
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Anti-MAEA / EMP Antibody (aa136-379) - LS-C295251 from LifeSpan Bioscience
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Anti-MAEA / EMP Antibody (N-Terminus) - LS-C345121 from LifeSpan Bioscience
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EMP/MAEA Antibody (730340) - MAB7288 from Novus Biologicals
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EMP/MAEA Antibody - AF7288 from Novus Biologicals
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EMP/MAEA Antibody - NBP2-14210 from Novus Biologicals
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EMP/MAEA Antibody - NBP2-17200 from Novus Biologicals
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EMP Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-12337R-A350 from Bioss
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EMP Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-12337R-A488 from Bioss
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EMP Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-12337R-A555 from Bioss
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EMP Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-12337R-A647 from Bioss
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