| Gene Symbol |
Carm1
|
| Entrez Gene |
59035
|
| Alt Symbol |
Prmt4
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
coactivator-associated arginine methyltransferase 1
|
| Other Description |
histone-arginine methyltransferase CARM1|protein arginine N-methyltransferase 4|protein arginine methyltransferase
|
| Swissprots |
Q91W24 Q8K1Y5 Q3TYB9 Q99KX8 Q9WVG6
|
| Accessions |
EDL25201 Q9WVG6 AF117887 AAD41265 AK158242 AK158757 BAE34644 AK188540 AK189449 AK202292 AK215861 BC003964 AAH03964 BC008263 AAH08263 BC026427 BC036974 AAH36974 BC071267 BU152197 BX529415 XM_006510519 XP_006510582 XM_006510520 XP_006510583 NM_021531 NP_067506 NM_153141 NP_694781
|
| Function |
Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activates transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte different
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Mainly nuclear during the G1, S and G2 phases of the cell cycle. Cytoplasmic during mitosis, after breakup of the nuclear membrane (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed. Within the brain, present in proliferating cells from lateral ventricular zone and dentate gyrus (at protein level). {ECO:0000269|PubMed:10381882, ECO:0000269|PubMed:16508003}.
|