Carm1

Gene Symbol Carm1
Entrez Gene 59035
Alt Symbol Prmt4
Species Mouse
Gene Type protein-coding
Description coactivator-associated arginine methyltransferase 1
Other Description histone-arginine methyltransferase CARM1|protein arginine N-methyltransferase 4|protein arginine methyltransferase
Swissprots Q91W24 Q8K1Y5 Q3TYB9 Q99KX8 Q9WVG6
Accessions EDL25201 Q9WVG6 AF117887 AAD41265 AK158242 AK158757 BAE34644 AK188540 AK189449 AK202292 AK215861 BC003964 AAH03964 BC008263 AAH08263 BC026427 BC036974 AAH36974 BC071267 BU152197 BX529415 XM_006510519 XP_006510582 XM_006510520 XP_006510583 NM_021531 NP_067506 NM_153141 NP_694781
Function Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activates transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte different
Subcellular Location Nucleus. Cytoplasm. Note=Mainly nuclear during the G1, S and G2 phases of the cell cycle. Cytoplasmic during mitosis, after breakup of the nuclear membrane (By similarity). {ECO:0000250}.
Tissue Specificity Ubiquitously expressed. Within the brain, present in proliferating cells from lateral ventricular zone and dentate gyrus (at protein level). {ECO:0000269|PubMed:10381882, ECO:0000269|PubMed:16508003}.

Recombinant Carm1 / Prmt4 protein - 31347 from ActiveMotif

Category Protein
Prices $395.00, $3,500.00
Sizes 10 µg, 1 mg
Source Baculovirus
Species Mouse
Recombinant Carm1 / Prmt4 protein gel. Carm1 / Prmt4 protein was run on an SDS-PAGE gel and stained with Coomassie blue.

Recombinant Carm1 E267Q protein - 31348 from ActiveMotif

Category Protein
Prices $395.00
Sizes 10 µg
Source Baculovirus
Species Mouse

Recombinant Mouse Histone-arginine methyltransferase CARM1(Carm1) - CSB-YP893004MO CSB-EP893004MO CSB-BP893004MO CSB-MP893004MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Recombinant Mouse CARM1 Protein - CARM1-2735M from Creative Biomart

Category Protein
Source Mammalian Cells
Species Mouse

Histone-arginine methyltransferase CARM1 (Carm1), Recombinant Protein - MBS1443461 from MyBioSource

Category Protein
Prices $1,400.00, $1,400.00, $1,630.00, $1,630.00, $2,360.00, $2,360.00, $2,805.00, $2,805.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse
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