| Gene Symbol |
KCND3
|
| Entrez Gene |
3752
|
| Alt Symbol |
KCND3L, KCND3S, KSHIVB, KV4.3, SCA19, SCA22
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, voltage gated Shal related subfamily D, member 3
|
| Other Description |
potassium ionic channel Kv4.3|potassium voltage-gated channel subfamily D member 3|potassium voltage-gated channel, Shal-related subfamily, member 3|sha1-related potassium channel Kv4.3|voltage-gated K+ channel|voltage-gated potassium channel subunit Kv4.3
|
| Swissprots |
Q9UH85 Q5T0M0 O60576 Q9UK17 O60577 Q9UH86 Q9UK16 Q14D71
|
| Accessions |
AAF68177 AAF68178 EAW56510 EAW56511 EAW56512 Q9UK17 AF048712 AAC05121 AF048713 AAC05122 AF120491 AAD38898 AF187963 AAF01044 AF187964 AAF01045 AF205856 AAF20924 AF205857 AAF20925 AY863198 AAX58111 BC113475 AAI13476 BC113477 AAI13478 BC143390 AAI43391 HQ258336 ADR83090 XM_005270851 XP_005270908 XM_006710629 XP_006710692 XM_006710630 XP_006710693 XM_006710631 XP_006710694 XM_006710632 XP_006710695 XM_011541425 XP_011539727 XM_011541426 XP_011539728 XM_011541427 XP_011539729 XM_011541428 XP_011539730 NM_004980 NP_004971 NM_172198 NP_751948
|
| Function |
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. {ECO:0000269|PubMed:10200233, ECO:0000269|PubMed:9843794}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein. Cell membrane, sarcolemma {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in heart and brain, in particular in cortex, cerebellum, amygdala and caudate nucleus. Detected at lower levels in liver, skeletal muscle, kidney and pancreas. Isoform 1 predominates in most tissues. Isoform 1 and isoform 2 are detected at similar levels in brain, skeletal muscle and pancreas. {ECO:0000269|PubMed:10200233, ECO:0000269|PubMed:10729221, ECO:0000269|PubMed:9843794}.
|