| Gene Symbol |
SLC17A8
|
| Entrez Gene |
246213
|
| Alt Symbol |
DFNA25, VGLUT3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 17 (vesicular glutamate transporter), member 8
|
| Other Description |
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8|solute carrier family 17 member 8|vesicular glutamate transporter 3
|
| Swissprots |
B7ZKV4 B3KXZ6 Q8NDX2 Q17RQ8
|
| Accessions |
EAW97637 Q8NDX2 AJ459241 CAD30553 AK128319 BAG54658 BC117229 AAI17230 BC143396 AAI43397 HQ258284 ADR83038 NM_001145288 NP_001138760 NM_139319 NP_647480
|
| Function |
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. {ECO:0000269|PubMed:12151341}.
|
| Subcellular Location |
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome {ECO:0000250}.
|
| Tissue Specificity |
Expressed in amygdala, cerebellum, hippocampus, medulla, spinal cord and thalamus. {ECO:0000269|PubMed:12151341}.
|
| Top Pathways |
Synaptic vesicle cycle, Glutamatergic synapse, Nicotine addiction, Retrograde endocannabinoid signaling
|